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Here, the design of the intelligent redox\u2010responsive generation 3 (G3) poly(amidoamine) dendrimer nanogels (NGs) loaded with gold nanoparticles (Au NPs) and chemotherapeutic drug toyocamycin (Au\/Toy@G3 NGs) for ultrasound\u2010enhanced cancer theranostics is showcased. The constructed hybrid NGs with a size of 193\u00a0nm possess good colloidal stability under physiological conditions, and can be dissociated to release Au NPs and Toy in the reductive glutathione\u2010rich tumor microenvironment (TME). The released Toy can promote the apoptosis of cancer cells through endoplasmic reticulum stress amplification and cause immunogenic cell death to maturate dendritic cells. The loaded Au NPs can induce the conversion of tumor\u2010associated macrophages from M2\u2010type to antitumor M1\u2010type to remodulate the immunosuppressive TME. Combined with antibody\u2010mediated immune checkpoint blockade, effective chemoimmunotherapy of a pancreatic tumor mouse model can be realized, and the chemoimmunotherapy effect can be further ultrasound enhanced due to the sonoporation\u2010improved tumor permeability of NGs. The developed Au\/Toy@G3 NGs also enable Au\u2010mediated computed tomography imaging of tumors. The constructed responsive dendrimeric NGs tackle tumors through a multi\u2010pronged chemoimmunotherapy strategy targeting both cancer cells and immune cells, which hold a promising potential for clinical translations.<\/jats:p>","DOI":"10.1002\/advs.202301759","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T20:39:03Z","timestamp":1687639143000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Redox\u2010Responsive Dendrimer Nanogels Enable Ultrasound\u2010Enhanced Chemoimmunotherapy of Pancreatic Cancer via Endoplasmic Reticulum Stress Amplification and Macrophage Polarization"],"prefix":"10.1002","volume":"10","author":[{"given":"Guizhi","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano\u2010Biomaterials and Regenerative Medicine College of 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