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Although chromo\u2010fluorogenic probes for detecting and quantifying MAO activity have been reported, non\u2010invasive methods for monitoring MAO overexpression in vivo remain elusive. Here, we report a renal\u2010clearable fluorogenic probe based on the cyanine\u20107 fluorophore (\n                    <jats:bold>Cy7\u2010MAO<\/jats:bold>\n                    ) for in vivo detection of MAO overexpression through a simple measurement of the fluorescence in urine. The probe incorporates sulfonic acid moieties for renal clearance and a propylamino group as a MAO substrate. Upon administration,\n                    <jats:bold>Cy7\u2010MAO<\/jats:bold>\n                    is hydrolysed at the site by MAO, releasing a highly emissive Cy7 fluorophore, which is excreted in urine and quantified by fluorescence.\n                    <jats:bold>Cy7\u2010MAO<\/jats:bold>\n                    is validated in vitro using HepG2 liver human cells, which express elevated MAO levels. We further demonstrate the in vivo applicability of\n                    <jats:bold>Cy7\u2010MAO<\/jats:bold>\n                    for MAO activity monitoring in aged mice, which show significantly higher urine fluorescence than young mice, consistent with an elevated MAO activity in older animals. These findings support\n                    <jats:bold>Cy7\u2010MAO<\/jats:bold>\n                    as a tool for longitudinal assessment of MAO activity in vivo, providing a novel approach to study MAO\u2010related pathologies.\n                  <\/jats:p>","DOI":"10.1002\/advs.202520797","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:51:55Z","timestamp":1773003115000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Renal Clearable Probe for In Vivo Monoamine Oxidase (MAO) Detection"],"prefix":"10.1002","volume":"13","author":[{"given":"Marcia","family":"Dom\u00ednguez","sequence":"first","affiliation":[{"name":"Instituto Interuniversitario de Investigaci\u00f3n de Reconocimiento Molecular y Desarrollo Tecnol\u00f3gico (IDM) Universitat Polit\u00e8cnica de Val\u00e8ncia Universitat de Val\u00e8ncia  Valencia Spain"},{"name":"CIBER de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER\u2010BBN) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Azor\u00edn\u2010Soriano","sequence":"additional","affiliation":[{"name":"Instituto Interuniversitario de Investigaci\u00f3n de Reconocimiento Molecular y Desarrollo Tecnol\u00f3gico (IDM) Universitat Polit\u00e8cnica de Val\u00e8ncia Universitat de Val\u00e8ncia  Valencia Spain"},{"name":"Unidad Mixta UPV\u2010CIPF de Investigaci\u00f3n en Mecanismos de Enfermedades y Nanomedicina, Universitat Polit\u00e8cnica de Val\u00e8ncia Centro de Investigaci\u00f3n Pr\u00edncipe Felipe  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Araceli","family":"L\u00e9rida\u2010Viso","sequence":"additional","affiliation":[{"name":"Instituto Interuniversitario de Investigaci\u00f3n de Reconocimiento Molecular y Desarrollo Tecnol\u00f3gico (IDM) Universitat Polit\u00e8cnica de Val\u00e8ncia Universitat de Val\u00e8ncia  Valencia Spain"},{"name":"CIBER de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER\u2010BBN) Instituto de Salud Carlos III  Madrid Spain"},{"name":"Unidad Mixta UPV\u2010CIPF de Investigaci\u00f3n en Mecanismos de Enfermedades y Nanomedicina, Universitat Polit\u00e8cnica de Val\u00e8ncia Centro de Investigaci\u00f3n Pr\u00edncipe Felipe  Valencia Spain"},{"name":"Unidad Mixta de Investigaci\u00f3n en Nanomedicina y Sensores Universitat Polit\u00e8cnica de Val\u00e8ncia Avenida Fernando Abril Martorell Instituto de Investigaci\u00f3n Sanitaria La Fe (IIS La Fe)  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessie","family":"Garc\u00eda\u2010Fleitas","sequence":"additional","affiliation":[{"name":"Instituto Interuniversitario de Investigaci\u00f3n de Reconocimiento Molecular y Desarrollo Tecnol\u00f3gico (IDM) Universitat Polit\u00e8cnica de Val\u00e8ncia Universitat de Val\u00e8ncia  Valencia Spain"},{"name":"CIBER de Bioingenier\u00eda, 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