{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T11:47:16Z","timestamp":1785757636009,"version":"3.56.0"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFC3508002"],"award-info":[{"award-number":["2025YFC3508002"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC2706700"],"award-info":[{"award-number":["2024YFC2706700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401948"],"award-info":[{"award-number":["82401948"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The age\u2010related decline in oocyte quality constitutes a major cause of reduced female fertility. In this study, we investigated the potential of stromal cell\u2010derived factor\u20101 (SDF\u20101) to counteract oocyte deterioration during reproductive aging. We observed a significant negative correlation between SDF\u20101 levels and aging in both human follicular fluid\/oocytes and murine ovarian tissues. Utilizing aged mouse models, we found that SDF\u20101 supplementation, both in vitro and in vivo, was associated with the amelioration of multiple aging\u2010associated oocyte defects, including restored meiotic spindle morphology, improved chromosomal alignment, normalized distribution of cortical granules and mitochondria, enhanced mitochondrial membrane potential, and reduced oxidative stress. Consequently, SDF\u20101 treatment improved fertilization competence, embryonic developmental potential, and fertility restoration in aged female mice. Mechanistically, transcriptomic and functional analyses suggested that SDF\u20101 ameliorates oocyte aging primarily by enhancing autophagic activity, which was associated with clearance of accumulated stress granules and mitigation of oxidative damage. Pharmacological inhibition of autophagy attenuated the beneficial effects of SDF\u20101. In conclusion, our findings point to a previously underexplored role for SDF\u20101 in alleviating age\u2010related oocyte decline, potentially through autophagy\u2010enhanced stress granule scavenging, positioning SDF\u20101 as a promising candidate for therapeutic intervention in reproductive aging, although further investigations are warranted in the future.<\/jats:p>","DOI":"10.1002\/advs.76902","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T11:10:08Z","timestamp":1785755408000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SDF\u20101 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy\u2010Enhanced Stress Granule Scavenging"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5047-2589","authenticated-orcid":false,"given":"Rui","family":"Long","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center, Tongji 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