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It affects a wide range of individuals, from recreational to elite athletes, and poses a substantial healthcare burden. This study proposes an AI\u2010enabled digital twin framework for sports health applications, offering both interpretability and clinical deployability. The framework identifies CAI and enables subtype stratification using a wearable electromyography (EMG) sensor\u2010driven hierarchical multi\u2010domain fusion model, generates fine\u2010grained motor function scores through a probabilistic modeling approach, and further translates the generated scores into clinically interpretable functional stratification to support rehabilitation assessment. SHapley Additive exPlanations (SHAP) \u2010 based interpretability reveals key predictive biomarkers underlying model decisions, establishing a transparent and closed\u2010loop framework for personalized rehabilitation. Validation on 150 participants, including CAI patients and healthy controls, confirms robust classification performance (Accuracy = 98.50%, AUC = 0.99), reliable discrimination of CAI subtypes (Accuracy = 87.70%, macro F1\u2010score = 87.20%), and strong concordance between the generated scores and the clinical gold\u2010standard scale (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a0\u22120.908, \u2005p\u2005 &lt; \u20050.001). This non\u2010invasive, personalized assessment framework supports long\u2010term rehabilitation management of chronic conditions, offering an innovative and cost\u2010effective digital health solution for sports medicine.\n                  <\/jats:p>","DOI":"10.1002\/advs.77212","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:21:47Z","timestamp":1788186107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Interpretable, Data\u2010Driven, Hierarchical Multi\u2010Domain Fusion Framework for Classification and Motor Function Scoring in Chronic Ankle Instability"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9227-1585","authenticated-orcid":false,"given":"Tianle","family":"Jie","sequence":"first","affiliation":[{"name":"Faculty of Sports Science Ningbo University  Ningbo China"},{"name":"Doctoral School on Safety and Security Sciences \u00d3buda 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Engineering Hong Kong Polytechnic University  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Auckland Bioengineering Institute University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibor J.","family":"Goda","sequence":"additional","affiliation":[{"name":"Doctoral School on Safety and Security Sciences \u00d3buda University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2187-9440","authenticated-orcid":false,"given":"Yaodong","family":"Gu","sequence":"additional","affiliation":[{"name":"Faculty of Sports Science Ningbo University  Ningbo 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