{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T01:10:19Z","timestamp":1759885819282,"version":"build-2065373602"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,6,17]],"date-time":"2004-06-17T00:00:00Z","timestamp":1087430400000},"content-version":"vor","delay-in-days":3365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AIChE Journal"],"published-print":{"date-parts":[[1995,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vortex flow filtration experiments with bovine serum albumin (BSA) solutions and Arthrobacter simplex cell suspensions in a rotary membrane device are modeled in the pressure\u2010dependent flux and mass\u2010transfer\u2010controlled regions. An expression for the concentration\u2010dependent diffusion coefficients accounting for hydrodynamic and long\u2010range potential interactions between rigid spherical macromolecules is used for BSA. A shear\u2010induced diffusion coefficient, strongly concentration\u2010dependent on the cell concentration, is assumed to describe the diffusion behavior of the cell suspensions. The adjusted model parameters for albumin solutions in the pressure\u2010dependent region of flux predict the permeation flux behavior for A. Simplex cell suspensions. When the mass\u2010transfer correlation is calculated using cell diffusion coefficients, based on a volumetric cell fraction that is around half of the average value of the calculated membrane surface fractions, the fluxes are estimated within less than 10.5% relative error. In the mass\u2010transfer\u2010controlled region of flux, the volume fractions of cells at the membrane surface are between 0.16 and 0.35, depending on bulk concentration and hydrodynamic conditions.<\/jats:p>","DOI":"10.1002\/aic.690410403","type":"journal-article","created":{"date-parts":[[2004,6,23]],"date-time":"2004-06-23T10:20:40Z","timestamp":1087986040000},"page":"764-772","source":"Crossref","is-referenced-by-count":6,"title":["Modeling membrane filtration of protein and cell suspensions in a vortex flow filtration system"],"prefix":"10.1002","volume":"41","author":[{"given":"M.","family":"Mateus","sequence":"first","affiliation":[]},{"given":"J. M. S.","family":"Cabral","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2004,6,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.432664"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2509(87)85057-1"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2509(90)80212-W"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022112077000111"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9797(78)90310-7"},{"volume-title":"Physical Biochemistry\u2014Applications to Biochemistry and Molecular Biology","year":"1982","author":"Freifelder D.","key":"e_1_2_1_7_1"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-71114-5"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/aic.690370811"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0017-9310(77)90084-9"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.38.10.863"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2509(86)85225-3"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022112087000880"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022112087002155"},{"key":"e_1_2_1_15_1","first-page":"149","article-title":"Crossflow Microfiltration of Cell Suspensions: A Review of Models with Emphasis on Particle Size Effects","volume":"70","author":"Lojkine M. H.","year":"1992","journal-title":"Trans. Inst. Chem. Eng."},{"key":"e_1_2_1_16_1","unstructured":"L\u00f3pez\u2010Leiva M. \u201cUltrafiltration in a Taylor Vortex Flow \u201d AIChE Meeting Boston (Aug. 19 1979)."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00369396"},{"key":"e_1_2_1_18_1","first-page":"279","article-title":"Pressure\u2010Driven Membrane Processes for Steroid Bioseparation: A Comparison of Membrane, Hydrodynamic and Operating Aspects","volume":"2","author":"Mateus M.","year":"1991","journal-title":"Biosep."},{"volume-title":"Recovery Processes for Biological Materials","year":"1993","author":"Mateus M.","key":"e_1_2_1_19_1"},{"issue":"12","key":"e_1_2_1_20_1","first-page":"31","article-title":"New Separation Technique for the Chemical Process Industries","volume":"64","author":"Michaels A. S.","year":"1968","journal-title":"Chem. Eng. Prog."},{"volume-title":"Physical Chemistry","year":"1962","author":"Moore W. J.","key":"e_1_2_1_21_1"},{"issue":"2","key":"e_1_2_1_22_1","first-page":"iii","article-title":"Improved Control of Ultrafiltration Using Vorticular Hydrodynamics and Hydrophilic Membranes","volume":"24","author":"Rolchigo P. M.","year":"1989","journal-title":"Process Biochem."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-7388(00)80987-4"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0376-7388(91)80042-5"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-7388(00)80723-1"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/00986448608911751"}],"container-title":["AIChE Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Faic.690410403","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aiche.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aic.690410403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:41:15Z","timestamp":1759884075000},"score":1,"resource":{"primary":{"URL":"https:\/\/aiche.onlinelibrary.wiley.com\/doi\/10.1002\/aic.690410403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,4]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1995,4]]}},"alternative-id":["10.1002\/aic.690410403"],"URL":"https:\/\/doi.org\/10.1002\/aic.690410403","archive":["Portico"],"relation":{},"ISSN":["0001-1541","1547-5905"],"issn-type":[{"type":"print","value":"0001-1541"},{"type":"electronic","value":"1547-5905"}],"subject":[],"published":{"date-parts":[[1995,4]]}}}