{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T15:04:31Z","timestamp":1773932671170,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2004,4,16]],"date-time":"2004-04-16T00:00:00Z","timestamp":1082073600000},"content-version":"vor","delay-in-days":958,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AIChE Journal"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Glucose was separated from fructose experimentally using a simulated moving\u2010bed (SMB) adsorber. A strongly acid cationic resin of gel type (Ca<jats:sup>2+<\/jats:sup> form) Dowex Monosphere (d<jats:sub>p<\/jats:sub> = 320 \u03bcm) was used in a pilot SMB unit of twelve 26 \u00d7 300 mm (ID \u00d7 length) columns. A recently proposed design procedure was applied to overcome the inherent strong mass\u2010transfer resistance present in this kind of adsorbent. The fluid\/solid velocity ratios in SMB sections 1, 2 and 3 leading to at least 90% product purity were followed by simulation and plotted in a 3\u2010D parameter space. The design methodology, called \u201cseparation volume analysis,\u201d also considered the geometric parameters, as well as allowable working flow rates, temperature and pressure of the plant. Operating conditions from this procedure were used to operate the SMB unit, and the expected performance was achieved experimentally. Simulation strategies based on a true countercurrent and a real SMB were used and the predicted performance of both agreed well with experimental data. Furthermore, experimental results confirmed predictions of the separation volume analysis, which shows the potential of the technique for optimizing existing SMB equipment.<\/jats:p>","DOI":"10.1002\/aic.690470915","type":"journal-article","created":{"date-parts":[[2004,4,16]],"date-time":"2004-04-16T14:04:16Z","timestamp":1082124256000},"page":"2042-2051","source":"Crossref","is-referenced-by-count":93,"title":["Fructose\u2013glucose separation in a SMB pilot unit: Modeling, simulation, design, and operation"],"prefix":"10.1002","volume":"47","author":[{"given":"Diana C. S.","family":"Azevedo","sequence":"first","affiliation":[]},{"given":"Al\u00edrio E.","family":"Rodrigues","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2004,4,16]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1081\/SS-100102356"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/aic.690450506"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/ie990115f"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(99)01136-X"},{"key":"e_1_2_1_6_1","unstructured":"Broughton D. B. andC. G.Gerhold \u201cContinuous Sorption Process Employing Fixed Bed of Sorbent and Moving Inlets and Outlets \u201d U.S. Patent No. 2 985 589 (1961)."},{"key":"e_1_2_1_7_1","first-page":"155","article-title":"High Purity Fructose via Continuous Adsorptive Separation","volume":"96","author":"Broughton D. 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