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Guided by the Resiliency Model of Family Stress, Adjustment, and Adaptation, the purpose of this cross\u2010country investigation, which is part of a larger, mixed methods study, was twofold: (1) to compare family adaptation in 12 countries, and (2) to examine the relationships between family variables and family adaptation. The focus of this study is data collected in the 12 countries where at least 30 parents completed the survey. Descriptive statistics were generated, and mean family adaptation was modeled in terms of each predictor independently, controlling for an effect on covariates. A parsimonious composite model for mean family adaptation was adaptively generated. While there were cross\u2010country differences, standardized family adaptation mean scores fell within the average range for all 12 countries. Key components of the guiding framework (i.e., family demands, family appraisal, family resources, and family problem\u2010solving communication) were important predictors of family adaptation. More cross\u2010country studies, as well as longitudinal studies, are needed to fully understand how culture and social determinants of health influence family adaptation in families of individuals with DS.<\/jats:p>","DOI":"10.1002\/ajmg.c.32075","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T10:19:27Z","timestamp":1699265967000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Family adaptation in families of individuals with <scp>Down<\/scp> syndrome from 12 countries"],"prefix":"10.1002","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5908-9033","authenticated-orcid":false,"given":"Marcia","family":"Van Riper","sequence":"first","affiliation":[{"name":"School of Nursing University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3639-5943","authenticated-orcid":false,"given":"George 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