{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T23:00:38Z","timestamp":1773702038581,"version":"3.50.1"},"reference-count":110,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Neurofilament light chain (NfL) quantification aids in diagnosing and predicting neurological disorders, but clinical and laboratory practices vary across centers. Differences in result interpretation and reporting further challenge test commutability. This study aimed to review the global analytical and post\u2010analytical methods used for NfL measurement in routine clinical practice across different contexts.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We established an international working group (WG) and distributed a survey to its members to gather information on context of use (COU), (pre) analytical methods, cutoff usage, as well as the interpretation and reporting of NfL measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Among the centers, 63% measured NfL in cerebrospinal fluid (CSF), 87% in blood, and 53% in both. COU was widespread, with 50% defining pathological cutoffs based on publications and 42% considering age. Reporting was primarily done through numeric results (95%).<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Harmonizing cutoffs, reporting, and interpretation across various clinical contexts will facilitate the incorporation of this biomarker into routine clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Unique international overview of current analytical and post\u2010analytical methods for neurofilament light chain (NfL) measurement in routine clinical practice.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Tailored sheets for each neurological application.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Strategies to harmonize cutoffs, reporting, and interpretation of NfL's measurement.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.70343","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T23:44:12Z","timestamp":1750722252000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical use and reporting of neurofilament quantification in neurological disorders: A global overview"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8606-6814","authenticated-orcid":false,"given":"Constance","family":"Delaby","sequence":"first","affiliation":[{"name":"Univ Montpellier, LBPC\u2010PPC, CHU Montpellier, INSERM  Montpellier France"},{"name":"Department of Unitat de Memoria Hospital de la Santa Creu iSant Pau \u2010 Biomedical Research Institute Sant Pau \u2010 Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}]},{"given":"Aur\u00e9lie","family":"Ladang","sequence":"additional","affiliation":[{"name":"Clinical chemistry department CHU de Li\u00e8ge  Li\u00e8ge Belgium"}]},{"given":"Jose","family":"Martinez\u2010Yriarte","sequence":"additional","affiliation":[{"name":"Clinical analysis service Hospital do Meixoeiro, \u00c1rea Sanitaria de Vigo  Vigo Spain"}]},{"given":"Chiara","family":"Zecca","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Diseases and the Aging Brain Department of Clinical Research in Neurology University of Bari \u201cA. Moro\u201d at Pia Fondazione \u201cCardinale G. Panico\"  Tricase Lecce Italy"}]},{"given":"Giancarlo","family":"Logroscino","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Diseases and the Aging Brain Department of Clinical Research in Neurology University of Bari \u201cA. Moro\u201d at Pia Fondazione \u201cCardinale G. Panico\"  Tricase Lecce Italy"}]},{"given":"Peter","family":"K\u00f6rtvelyessy","sequence":"additional","affiliation":[{"name":"Department of Neurology Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Department of Neurology German Center for Neurodegenerative Diseases (DZNE)  Magdeburg Germany"},{"name":"Labor Berlin, Division Innovation  Berlin Germany"}]},{"given":"Hayrettin","family":"Tumani","sequence":"additional","affiliation":[{"name":"CSF Laboratory University of Ulm  Ulm Germany"}]},{"given":"Piero","family":"Parchi","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences (DiBiNeM) University of Bologna  Bologna Italy"},{"name":"Department of Clinical Neurobiology IRCCS Istituto delle Scienze Neurologiche di Bologna  Bologna Italy"}]},{"given":"Isabelle","family":"Quadrio","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Biology Department Neurodegenerative Pathologies LBMMS Hospices Civils de Lyon, BIORAN Team Lyon Neurosciences Research Center CNRS UMR 5292 INSERM U1028  Lyon France"}]},{"given":"Melanie","family":"Hart","sequence":"additional","affiliation":[{"name":"Department of Neuroinflammation UCL Queen Square Institute of Neurology  London UK"}]},{"given":"Dorte Aalund","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology University hospital of southern Denmark, Odense  Southern Denmark Denmark"}]},{"given":"Daniel","family":"Alcolea","sequence":"additional","affiliation":[{"name":"Department of Unitat de Memoria Hospital de la Santa Creu iSant Pau \u2010 Biomedical Research Institute Sant Pau \u2010 Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Department of Neurology Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas, CIBERNED  Barcelona Spain"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurochemistry University of Gothenburg, M\u00f6lndal  Gothenburg Sweden"}]},{"given":"Juan","family":"Fortea","sequence":"additional","affiliation":[{"name":"Department of Unitat de Memoria Hospital de la Santa Creu iSant Pau \u2010 Biomedical Research Institute Sant Pau \u2010 Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Department of Neurology Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas, CIBERNED  Barcelona Spain"}]},{"given":"Alberto","family":"Lleo","sequence":"additional","affiliation":[{"name":"Department of Unitat de Memoria Hospital de la Santa Creu iSant Pau \u2010 Biomedical Research Institute Sant Pau \u2010 Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Department of Neurology Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas, CIBERNED  Barcelona Spain"}]},{"given":"Alicia","family":"Algeciras\u2010Schimnich","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota USA"}]},{"given":"Xavier","family":"Ayrignac","sequence":"additional","affiliation":[{"name":"Department of Neurology CHU Montpellier, INSERM, Universit\u00e9 Montpellier  Montpellier France"}]},{"given":"Aur\u00e9lie","family":"Bedel","sequence":"additional","affiliation":[{"name":"Department of Biochimie CHU de Bordeaux INSERM BRIC U1312 Universit\u00e9 de Bordeaux  Bordeaux France"}]},{"given":"Gustavo A. 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