{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:03:14Z","timestamp":1790334194721,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001779","name":"Monash University","doi-asserted-by":"publisher","award":["U19AG062682"],"award-info":[{"award-number":["U19AG062682"]}],"id":[{"id":"10.13039\/501100001779","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG029824"],"award-info":[{"award-number":["U01AG029824"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008018","name":"Victorian Cancer Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Aspirin is not recommended for dementia prevention due to limited benefit. We investigated whether genetic subgroups may benefit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      In the ASPirin in Reducing Events in the Elderly (ASPREE) trial (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a013,541), we screened 5182 polygenic risk scores (PGSs) for aspirin interactions on dementia and major bleeding. After quality control, 1848 PGSs were analyzed using Cox models for aspirin\u00d7PGS interaction, adjusted for age, sex,\n                      <jats:italic>apolipoprotein E<\/jats:italic>\n                      status, and ancestry. Interactions were Bonferroni\u2010corrected and examined by quintiles.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Platelet\u2010related PGS accounted for 18\/112 nominally significant interactions (enrichment_OR\u00a0=\u00a054.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a03.1 \u00d7 10\n                      <jats:sup>\u2212<\/jats:sup>\n                      <jats:sup>1<\/jats:sup>\n                      <jats:sup>8<\/jats:sup>\n                      ). Three highly correlated platelet\u2010count PGSs passed multiple testing. For participants in the highest quintile of the platelet\u2010count PGS003548, aspirin allocation was associated with a 3.5\u2010fold reduction in incident dementia versus placebo (hazard ratio [HR]: 0.28, 95% confidence interval [CI]: 0.15 to 0.52). Major bleeding was also increased (HR: 2.13, 95% CI: 1.36 to 3.34). Similar interactions were observed using the highest PGS003548 tertile, decile, and 5%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Platelet count\u2010related genetic variation may modify aspirin effects on dementia. These hypothesis\u2010generating findings require validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71817","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:03:38Z","timestamp":1790247818000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Platelet count polygenic scores may modify the effect of aspirin in primary prevention of dementia"],"prefix":"10.1002","volume":"22","author":[{"given":"Peter D.","family":"Fransquet","sequence":"first","affiliation":[{"name":"School of Public Health and Preventive MedicineFaculty of Medicine, Nursing and Health Sciences Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglong","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive MedicineFaculty of Medicine, Nursing and Health Sciences Monash University  Melbourne Victoria Australia"},{"name":"Victorian Heart Institute Monash University  Clayton Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cammie","family":"Tran","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive MedicineFaculty of Medicine, Nursing and Health Sciences Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sultana Monira","family":"Hussain","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive MedicineFaculty of Medicine, Nursing and Health Sciences Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Brodtmann","sequence":"additional","affiliation":[{"name":"Department of Neuroscience School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences Monash University  Melbourne Victoria 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