{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:51:15Z","timestamp":1791460275431,"version":"4.3.4"},"reference-count":53,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008320","name":"Suomen Aivos\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>We examined whether comorbidities and health\u2010care use differ between individuals later diagnosed with early\u2010onset Alzheimer's disease (EOAD) and matched controls during the 15 years preceding diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This population\u2010based case\u2013control study included 407 EOAD patients diagnosed at two Finnish university hospitals (2010\u20132021), and 4035 age\u2010 and sex\u2010matched controls. Prior diagnoses and health\u2010care visits were obtained from nationwide registers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      EOAD patients had higher prevalence of vertigo (5.9%\u00a0vs. 2.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), depression (5.7%\u00a0vs. 2.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), headache (4.9%\u00a0vs. 1.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), delirium (1.5%\u00a0vs. 0.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), brain injuries (2.9%\u00a0vs. 0.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002), thyroid disorders (2.5%\u00a0vs. 0.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.008), alcohol\u2010related disorders (3.4%\u00a0vs. 1.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.009), epilepsy (2.2%\u00a0vs. 0.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.009), strokes (4.4%\u00a0vs. 2.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.008), and otorhinolaryngologic diseases (5.2%\u00a0vs. 2.9%,\n                      <jats:italic>p<\/jats:italic>\n                      =\u00a00.027) 1\u20135 years before diagnosis. Only otorhinolaryngologic diseases (4.7%\u00a0vs. 2.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.036) differed 6 to 10 years prior, whereas no differences were seen 11 to 15 years before diagnosis. Hypertension and dyslipidemia showed no between\u2010group differences. Health\u2010care use increased markedly from year before EOAD diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>EOAD is preceded by recognizable patterns of morbidity and increased health\u2010care use, which may support earlier detection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71831","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:00:43Z","timestamp":1791457243000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comorbidities and health\u2010care use prior to early\u2010onset Alzheimer's disease: A population\u2010based case\u2013control study"],"prefix":"10.1002","volume":"22","author":[{"given":"Laura","family":"Lepp\u00e4nen","sequence":"first","affiliation":[{"name":"Research Unit of Clinical Medicine, Neurology University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfina","family":"Lehtonen","sequence":"additional","affiliation":[{"name":"Research Unit of Clinical Medicine, Neurology University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Aaltonen","sequence":"additional","affiliation":[{"name":"Law School University of Eastern Finland  Joensuu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalle","family":"Aho","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine\u2013Neurology University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ave","family":"Kivisild","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine\u2013Neurology University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbe","family":"Ullgren","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine\u2013Neurology University of Eastern Finland  Kuopio Finland"},{"name":"Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet  Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iina","family":"Rinnankoski","sequence":"additional","affiliation":[{"name":"Research Unit of Clinical Medicine, Neurology University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmi","family":"Soppela","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine\u2013Neurology University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annakaisa","family":"Haapasalo","sequence":"additional","affiliation":[{"name":"A.I. 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