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Exposures included eGFR level and variability. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) and brain structure by magnetic resonance imaging (MRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In META\u2010KLS, higher cumulative eGFR was associated with higher MoCA scores (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a00.350; 95% confidence interval [CI]: 0.148 to 0.552), whereas greater eGFR variability was associated with lower MoCA scores (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22120.454; 95% CI: \u22120.659 to \u22120.250). Across cohorts, higher eGFR was associated with white matter, superior frontal, and middle temporal volumes. In META\u2010KLS, greater variability showed nominal inverse associations with inferior parietal and middle temporal volumes and reduced rostral anterior cingulate cortex thickness.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Lower eGFR and greater eGFR variability were associated with lower MoCA scores and region\u2010specific structural brain alterations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71840","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T07:17:13Z","timestamp":1790147833000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Kidney function and brain health: cognitive and structural signatures across cohorts"],"prefix":"10.1002","volume":"22","author":[{"given":"Min","family":"Li","sequence":"first","affiliation":[{"name":"Clinical Epidemiology and EBM Unit Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Radiology Kailuan General Hospital  Tangshan Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijing","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Radiology Kailuan General Hospital  Tangshan Hebei 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