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However, selecting specific exposure domains, identifying metrics, and downloading, processing, and managing big data are key challenges in translating the potential of exposome research into empirical data analyses. To overcome these issues, we have established a reproducible system that protects data privacy, setting the stage for an unparalleled examination of associations between environmental exposures and ADRD risk within an exposome framework. In this perspective, we provide a comprehensive guide, including examples, to linking natural, built, and social environment metrics to nationwide time\u2010varying participants\u2019 residential address data. Further, as a proof of concept, we report descriptive statistics and spatial distribution of external exposome metrics across the contiguous United States in 2015. The external exposome can be securely and comprehensively characterized across multiple cohorts using this highly scalable approach.<\/jats:p>","DOI":"10.1002\/alz.71841","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:59:37Z","timestamp":1790650777000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Practical considerations for characterization of the external exposome in Alzheimer's disease and related dementias cohorts"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7935-5300","authenticated-orcid":false,"given":"Zachary","family":"Popp","sequence":"first","affiliation":[{"name":"Center for Climate and Health Boston University School of Public Health  Boston Massachusetts USA"},{"name":"Department of Environmental Health Boston University School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"James","sequence":"additional","affiliation":[{"name":"Center for Climate and Health Boston University School of Public Health  Boston Massachusetts USA"},{"name":"Department of Environmental Health Boston University School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Chivardi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Boston University School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron J","family":"Reimer","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Boston University School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Robbins","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Boston University School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Jenson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Boston University School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen M","family":"van Baar","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Boston University School of Public Health  Boston Massachusetts USA"},{"name":"Department of Epidemiology Columbia University Mailman School of Public Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"James","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences School of Medicine University of California Davis  Davis California USA"},{"name":"Department of Environmental Health Harvard T. 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