{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:55:12Z","timestamp":1790654112686,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG075758"],"award-info":[{"award-number":["R01AG075758"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 allele has weaker association with ADRD outcomes in Hispanic\/Latino populations compared to non\u2010Hispanic White and East Asian populations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We used whole\u2010genome sequencing data from 13,025 Hispanic\/Latino adults to infer population groups (clusters) from short DNA sequences at the\n                      <jats:italic>APOE<\/jats:italic>\n                      gene region. We estimated the associations between these clusters and mild cognitive impairment (MCI) and age\u2010adjusted significant cognitive decline assessed via the Study of Latinos\u2010Investigation of Neurocognitive Aging (SOL\u2010INCA) study (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a05334). We compared these associations to those of the conventional\n                      <jats:italic>APOE<\/jats:italic>\n                      alleles.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      We identified three clusters of individuals. Relative to the largest Cluster 1, being in Cluster 3 had higher likelihood of having significant cognitive decline, with odds ratio (OR)\u00a0=\u00a01.47, 95% confidence interval (CI) [1.18, 1.84],\n                      <jats:italic>p<\/jats:italic>\n                      &lt;\u00a00.001. The association with having prevalent MCI at the SOL\u2010INCA exam was not statistically significant, with OR\u00a0=\u00a01.33, 95% CI [0.97, 1.83],\n                      <jats:italic>p<\/jats:italic>\n                      =\u00a00.08. Associations of the \u03b54 allele with these traits were not statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      The new\n                      <jats:italic>APOE<\/jats:italic>\n                      profile has stronger risk association with age\u2010adjusted significant cognitive decline in SOL\u2010INCA Hispanics\/Latinos compared to the \u03b54 allele.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71855","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:58:29Z","timestamp":1790650709000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel genetic profile linked to cognitive decline in Hispanics\/Latinos"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4683-8883","authenticated-orcid":false,"given":"Yana","family":"Hrytsenko","sequence":"first","affiliation":[{"name":"Cardiovascular division Beth Israel Deaconess Medical Center  Boston Massachusetts USA"},{"name":"Department of Medicine Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogesh","family":"Purushotham","sequence":"additional","affiliation":[{"name":"Cardiovascular division Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhirou","family":"Li","sequence":"additional","affiliation":[{"name":"Cardiovascular division Beth Israel Deaconess Medical Center  Boston Massachusetts USA"},{"name":"Department of Biostatistics Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen R","family":"Isasi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Population Health Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wassim","family":"Tarraf","sequence":"additional","affiliation":[{"name":"Institute of Gerontology &amp; Department of Healthcare Sciences Wayne State University  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto R","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha L","family":"Daviglus","sequence":"additional","affiliation":[{"name":"Department of Medicine, Institute for Minority Health Research University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Humberto","family":"Parada","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Biostatistics, School of Public Health San Diego State University  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian W","family":"Spitzer","sequence":"additional","affiliation":[{"name":"Cardiovascular division Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Isshiki","sequence":"additional","affiliation":[{"name":"Departments of Genetics Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srilakshmi M","family":"Raj","sequence":"additional","affiliation":[{"name":"Departments of Genetics Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"DeCarli","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California Davis  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector M","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Fornage","sequence":"additional","affiliation":[{"name":"Brown Foundation Institute of Molecular Medicine, McGovern Medical School University of Texas Health Science Center at Houston  Houston Texas USA"},{"name":"Human Genetics Center, Department of Epidemiology, School of Public Health The University of Texas Health Science Center at Houston  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Sofer","sequence":"additional","affiliation":[{"name":"Cardiovascular division Beth Israel Deaconess Medical Center  Boston Massachusetts USA"},{"name":"Department of Medicine Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Biostatistics Harvard T.H. 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