{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:00:46Z","timestamp":1790650846981,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000125","name":"National Institute for Occupational Safety and Health","doi-asserted-by":"publisher","award":["U01OH011314"],"award-info":[{"award-number":["U01OH011314"]}],"id":[{"id":"10.13039\/100000125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000125","name":"National Institute for Occupational Safety and Health","doi-asserted-by":"publisher","award":["R01AG049953"],"award-info":[{"award-number":["R01AG049953"]}],"id":[{"id":"10.13039\/100000125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000125","name":"National Institute for Occupational Safety and Health","doi-asserted-by":"publisher","award":["R01AG067590"],"award-info":[{"award-number":["R01AG067590"]}],"id":[{"id":"10.13039\/100000125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000125","name":"National Institute for Occupational Safety and Health","doi-asserted-by":"publisher","award":["P30 AG066514"],"award-info":[{"award-number":["P30 AG066514"]}],"id":[{"id":"10.13039\/100000125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007625","name":"Cure Alzheimer's Fund","doi-asserted-by":"publisher","award":["R01AG084699"],"award-info":[{"award-number":["R01AG084699"]}],"id":[{"id":"10.13039\/100007625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007625","name":"Cure Alzheimer's Fund","doi-asserted-by":"publisher","award":["R01AG093879"],"award-info":[{"award-number":["R01AG093879"]}],"id":[{"id":"10.13039\/100007625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007625","name":"Cure Alzheimer's Fund","doi-asserted-by":"publisher","award":["R01AG093281"],"award-info":[{"award-number":["R01AG093281"]}],"id":[{"id":"10.13039\/100007625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Exposure to aerosolized pollutants is a risk factor for cognitive impairment and dementia, but the specific features of exposure\u2010related neurodegeneration remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We measured the World Trade Center Neurotoxicant Exposure Severity Index (WTC\u2010NESI) in 218 responders and unexposed controls aged 44\u201065 years. The main outcome was cortical thickness. Correlation analyses reported unadjusted associations and multiple linear regression to adjust for correlates. Vertex\u2010wise analyses were used with threshold\u2010free cluster enhancement to examine associations after adjusting for cross\u2010vertex clustering in atrophy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Cortical thickness was associated with WTC\u2010NESI (\n                      <jats:italic>R\u00a0=<\/jats:italic>\n                      \u00a0\u22120.38,\n                      <jats:italic>p\u00a0&lt;<\/jats:italic>\n                      \u00a00.001) that survived multivariable adjustment. Vertex\u2010wise analyses revealed reduced cortical thickness across much of the cortical surface that was associated with WTC exposure severity. Results were right\u2010hemisphere asymmetric and focused in the precentral regions (partial\n                      <jats:italic>\n                        \u03b7\n                        <jats:sup>2<\/jats:sup>\n                      <\/jats:italic>\n                      \u2265 0.07).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Our results provide an important reference for neurotoxicological investigators mapping the implications of airborne pollutant exposures. This study suggests that efforts to mitigate exposures in first responders might have long\u2010term implications for cerebral health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71878","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:53:48Z","timestamp":1790650428000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["World Trade Center neurotoxicant exposure severity is associated with cortical thinning and regional brain atrophy: a neuroimaging study of general responders at midlife"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6124-0329","authenticated-orcid":false,"given":"Sean A. P.","family":"Clouston","sequence":"first","affiliation":[{"name":"Program in Public Health Renaissance School of Medicine at Stony Brook University  Stony Brook New York USA"},{"name":"Department of Family, Population, and Preventive Medicine Renaissance School of Medicine at Stony Brook University  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Sciences Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Temurbek","family":"Askarov","sequence":"additional","affiliation":[{"name":"Department of Chemistry Stony Brook University  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Division of Neuroradiology Renaissance School of Medicine at Stony Brook University  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zan","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"World Trade Center Health and Wellness Program  Commack New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa A.","family":"Carr","sequence":"additional","affiliation":[{"name":"World Trade Center Health and Wellness Program  Commack New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Program in Public Health Renaissance School of Medicine at Stony Brook University  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"West","sequence":"additional","affiliation":[{"name":"Department of Radiology Division of Neuroradiology Renaissance School of Medicine at Stony Brook University  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank D.","family":"Mann","sequence":"additional","affiliation":[{"name":"Program in Public Health Renaissance School of Medicine at Stony Brook University  Stony Brook New York USA"},{"name":"Department of Medicine Renaissance School of Medicine at Stony Brook University  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Marquez","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences Robert Stempel College of Public Health and Social Work, Florida International University  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Vaska","sequence":"additional","affiliation":[{"name":"Department of Radiology Division of Neuroradiology Renaissance School of Medicine at Stony Brook University  Stony Brook New York USA"},{"name":"Department of Biomedical Engineering Stony Brook University  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