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Plasma amyloid beta (A\u03b2) 42 and 40 were measured via mass spectrometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Frontal slow\u2010wave activity (SWA) was inversely associated with plasma A\u03b242\/40 at cross\u2010section in bivariate analysis and in a covariate\u2010adjusted model. In comparison, low rapid eye movement (REM) sleep percentage was associated with a large longitudinal decline in annualized blood\u2010based A\u03b242\/40. In exploratory analyses, the association between low REM sleep percentage and faster decline in A\u03b242\/40 ratio was stronger in the amyloid\u2010positive group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>In cognitively unimpaired older adults, non\u2010REM SWA correlates with cross\u2010sectional amyloid load, whereas REM sleep may predict accelerated amyloid accumulation in preclinical stage, suggesting both may serve as early biomarkers and modifiable interventional targets.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71910","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:53:47Z","timestamp":1791546827000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal associations of rapid eye movement (REM) sleep and slow\u2010wave sleep with plasma Alzheimer's disease biomarkers"],"prefix":"10.1002","volume":"22","author":[{"given":"Jeongyeon","family":"Hwang","sequence":"first","affiliation":[{"name":"The Barbara and Maurice Deane Center for Wellness and Cognitive Health, Department of Neurology Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"David M. 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