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Dementia"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Cognitive composites offer greater sensitivity to amyloid beta (A\u03b2)\u2010related decline compared to individual tests for tracking longitudinal cognitive change. We developed and validated data\u2010driven composites from the harmonized Alzheimer's Dementia Onset and Progression in International Cohorts (ADOPIC) study, addressing gaps in psychometric reporting and multi\u2010cohort validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The study included 1964 cognitively unimpaired (CU) participants at baseline (longitudinal subset\u00a0=\u00a01110). Principal component analysis\u2010derived domain\u2010specific and general cognitive composites were evaluated for psychometric properties, sensitivity to A\u03b2\u2010related decline, and mild cognitive impairment (MCI) progression prediction compared to the Alzheimer's Disease Cooperative Study \u2013 Preclinical Alzheimer's Cognitive Composite (ADCS\u2010PACC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Proposed composites demonstrated good to excellent psychometric properties and sensitivity to differentiating CU A\u03b2 trajectories (p\u00a0&lt;\u00a00.001). General cognition demonstrated longitudinal sensitivity comparable to the ADCS\u2010PACC (d\u00a0=\u00a0\u22120.20) and equivalent classification performance (area under the receiver operating characteristic curve =\u00a00.70). All composites significantly predicted MCI progression (p\u00a0&lt;\u00a00.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The composites perform comparably to the ADCS\u2010PACC, developed for CU with A\u03b2, in longitudinal sensitivity while providing comprehensive psychometric characterization and domain\u2010specific measurement, supporting their utility as outcome measures in preclinical Alzheimer's disease studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71917","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:59:34Z","timestamp":1791773974000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Data\u2011driven cognitive composites predict A\u03b2\u2011related decline and progression to MCI: the ADOPIC study"],"prefix":"10.1002","volume":"22","author":[{"given":"Bhargav","family":"Tallapragada","sequence":"first","affiliation":[{"name":"Centre for Healthy Ageing, Health Futures Institute Murdoch University  Murdoch Western Australia Australia"},{"name":"School of Psychology Murdoch University  Murdoch Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brook","family":"Galna","sequence":"additional","affiliation":[{"name":"Centre for Healthy Ageing, Health Futures Institute Murdoch University  Murdoch Western Australia Australia"},{"name":"School of Allied Health (Exercise Science) Murdoch University  Murdoch Western Australia Australia"},{"name":"Personalised Medicine Centre, Health Futures Institute Murdoch University  Murdoch Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosita","family":"Shishegar","sequence":"additional","affiliation":[{"name":"The Australian e\u2010Health Research Centre, 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Francisco  San Francisco California USA"},{"name":"Departments of Radiology and Biomedical Imaging, Medicine, Psychiatry, and Neurology University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Weiner","sequence":"additional","affiliation":[{"name":"Center for Imaging of Neurodegenerative Diseases University of California\u2010San Francisco  San Francisco California USA"},{"name":"Departments of Radiology and Biomedical Imaging, Medicine, Psychiatry, and Neurology University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph N.","family":"Martins","sequence":"additional","affiliation":[{"name":"Alzheimer's Research Australia, Sarich Neuroscience Research Institute  Nedlands Western Australia Australia"},{"name":"Macquarie Medical School Macquarie University  Sydney New South Wales Australia"},{"name":"Faculty of Medicine The University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Morris","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin L.","family":"Masters","sequence":"additional","affiliation":[{"name":"Alzheimer's Research Australia, Sarich Neuroscience Research Institute  Nedlands Western Australia Australia"},{"name":"Faculty of Medicine The University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Maruff","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health The University of Melbourne  Parkville Victoria Australia"},{"name":"Cogstate Ltd  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8017-8682","authenticated-orcid":false,"given":"Hamid R.","family":"Sohrabi","sequence":"additional","affiliation":[{"name":"Centre for Healthy Ageing, Health Futures Institute Murdoch University  Murdoch Western Australia Australia"},{"name":"School of Psychology Murdoch University  Murdoch Western Australia Australia"},{"name":"Alzheimer's Research Australia, Sarich Neuroscience Research Institute  Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"of ADOPIC study","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.dadm.2016.09.002","article-title":"Cognitive impairment and decline in cognitively normal older adults with high 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