{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T02:56:48Z","timestamp":1767841008082,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"S6","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cognitive loss following COVID\u201019 has been recognized as an acute and long\u2010term sequela of the disease, with deficits in attention, executive functioning, and memory (Panagea et al., 2024; Hampshire et al., 2021). Older adults from racial and ethnic minority backgrounds face heightened risks of severe COVID\u201019 outcomes due to aging\u2010related vulnerabilities and a higher prevalence of comorbidities, yet post\u2010infection cognitive impairment in these populations remains unexplored. Prior studies have been limited by suboptimal assessments, and recruitment of predominantly non\u2010Hispanic White adults. Our pilot study, therefore, aims to address this gap by examining the relationship between persistent COVID\u201019 symptoms, and cognitive outcomes in a small sample of racially\/ethnically diverse older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>20 participants were engaged from Mount Sinai's COVID\u201019 Biobank (mean age 63.4 \u00b1 4.9 years; 14.6 \u00b1 3.9 years of education; 55% male; race\/ethnicity: 45% Black, 15% Hispanic, 5% Asian, 35% non\u2010Hispanic White), and hospitalized in 2020. Inclusion criteria were: (1) History of SARS\u2010CoV\u20102 infection or serum antibody positive (2) age \u226555, and (3) English\u2010speaking. Participants were remotely administered the NACC UDS 3.0 and several questionnaires, including one assessing persistent COVID\u201019 symptoms. Univariate analyses were used to compare demographic characteristics between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      No group differences were found between participants with and without loss of smell\/taste\n                      <jats:italic>during<\/jats:italic>\n                      infection. However, those with\n                      <jats:italic>long\u2010term<\/jats:italic>\n                      loss of smell\/taste (&gt;4 weeks) scored significantly lower on CERAD total, delay, and recognition (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.016, 0.042). Additionally, longer hospitalization durations were significantly associated with poorer global cognition (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001), verbal memory (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.014), auditory working memory (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.043), simple attention and processing speed (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), as well as verbal fluency (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Participants with\n                      <jats:italic>long\u2010term<\/jats:italic>\n                      loss of smell\/taste and longer hospitalization had persistent cognitive impairment approximately 2.9 years post COVID\u201019 infection. Therefore, findings suggest the importance of studying the long\u2010term role of infections similar to COVID\u201019 on Alzheimer's Disease and Related\u2010Dementias (AD\/ADRD) risk, particularly in a diverse sample of older populations. Further research with larger, longitudinal samples is needed to clarify the underlying mechanisms and inform cognitive rehabilitation strategies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz70860_107571","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T19:40:48Z","timestamp":1766518848000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A pilot study to examine COVID\u201019 induced cognitive loss in diverse older populations"],"prefix":"10.1002","volume":"21","author":[{"given":"Mahmood","family":"Mohamed","sequence":"first","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shreya","family":"Upendra","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankit","family":"Parekh","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Spat\u2010Lemus","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Drew","family":"Melancon","sequence":"additional","affiliation":[{"name":"Montclair State University, Montclair, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiuyu","family":"Au","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiyu","family":"Cao","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Li","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,23]]},"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz70860_107571","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T21:50:54Z","timestamp":1767822654000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz70860_107571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":0,"journal-issue":{"issue":"S6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/alz70860_107571"],"URL":"https:\/\/doi.org\/10.1002\/alz70860_107571","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-12-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e107571"}}