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SARS\u2010CoV\u20102\u2013specific antibody index and SARS\u2010CoV\u20102 RNA were studied in cerebrospinal fluid following COVID\u201019. Cerebrospinal fluid was assessed between days 1 and 30 (n\u00a0=\u00a012), between days 31 and 90 (n\u00a0=\u00a08), or later than 90\u2009days (post\u2013COVID\u201019, n\u00a0=\u00a020) after COVID\u201019 diagnosis. SARS\u2010CoV\u20102 RNA was absent in all patients, and in none of the 20 patients with post\u2013COVID\u201019 syndrome were intrathecally produced anti\u2013SARS\u2010CoV\u20102 antibodies detected. The absence of evidence of SARS\u2010CoV\u20102 in cerebrospinal fluid argues against a persistent central nervous system infection as a cause of neurological or neuropsychiatric post\u2013COVID\u201019 syndrome. 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