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However, many approaches require design and synthesis of complex ligands or formulation of nanoparticles which often perform poorly in living cells. This work reports on a method for the generation of an active palladium species that triggers bond\u2010cleaving reactions inside living cells. We utilized the water\u2010soluble Na<jats:sub>2<\/jats:sub>PdCl<jats:sub>4<\/jats:sub> as a simple source of Pd<jats:sup>II<\/jats:sup> which can be intracellularly reduced by sodium ascorbate to the active Pd<jats:sup>0<\/jats:sup> species. Once generated, Pd<jats:sup>0<\/jats:sup> triggers the cleavage of allyl ether and carbamate caging groups leading to the release of biologically active molecules. 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