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Here, we describe the first small\u2010molecule drug conjugates for the treatment of carbonic anhydrase IX expressing solid tumors. Using ligand\u2013dye conjugates we demonstrate that such molecules can preferentially accumulate inside antigen\u2010positive lesions, have fast targeting kinetics and good tumor\u2010penetrating properties, and are easily accessible by total synthesis. A disulfide\u2010linked drug conjugate with the maytansinoid DM1 as the cytotoxic payload and a derivative of acetazolamide as the targeting ligand exhibited a potent antitumor effect in SKRC52 renal cell carcinoma in vivo. It was furthermore superior to sunitinib and sorafenib, both small\u2010molecule standard\u2010of\u2010care drugs for the treatment of kidney cancer.<\/jats:p>","DOI":"10.1002\/anie.201310709","type":"journal-article","created":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T12:45:49Z","timestamp":1394628349000},"page":"4231-4235","source":"Crossref","is-referenced-by-count":267,"title":["A Small\u2010Molecule Drug Conjugate for the Treatment of Carbonic Anhydrase IX Expressing Tumors"],"prefix":"10.1002","volume":"53","author":[{"given":"Nikolaus","family":"Krall","sequence":"first","affiliation":[]},{"given":"Francesca","family":"Pretto","sequence":"additional","affiliation":[]},{"given":"Willy","family":"Decurtins","sequence":"additional","affiliation":[]},{"given":"Gon\u00e7alo J. 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