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Although such CORMs have showed promising results in the treatment of a number of animal models of disease, they still lack the necessary attributes for clinical development. Described in this Minireview are the methods used for CORM selection, to date, and how new insights into the reactivity of metal\u2010carbonyl complexes in\u2005vivo, together with advances in methods for live\u2010cell CO detection, are driving the design and synthesis of new CORMs, CORMs that will enable controlled CO release in\u2005vivo in a spatial and temporal manner without affecting oxygen transport by hemoglobin.<\/jats:p>","DOI":"10.1002\/anie.201311225","type":"journal-article","created":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T21:39:39Z","timestamp":1406583579000},"page":"9712-9721","source":"Crossref","is-referenced-by-count":325,"title":["Carbon\u2010Monoxide\u2010Releasing Molecules for the Delivery of Therapeutic CO In\u2005Vivo"],"prefix":"10.1002","volume":"53","author":[{"given":"Sandra","family":"Garc\u00eda\u2010Gallego","sequence":"first","affiliation":[]},{"given":"Gon\u00e7alo J. 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