{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T17:05:00Z","timestamp":1772211900418,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T00:00:00Z","timestamp":1417651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2015,1,19]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We demonstrate that Ru<jats:sup>II<\/jats:sup>(CO)<jats:sub>2<\/jats:sub>\u2013protein complexes, formed by the reaction of the hydrolytic decomposition products of [<jats:italic>fac<\/jats:italic>\u2010RuCl(<jats:italic>\u03ba<\/jats:italic><jats:sup>2<\/jats:sup>\u2010H<jats:sub>2<\/jats:sub>NCH<jats:sub>2<\/jats:sub>CO<jats:sub>2<\/jats:sub>)(CO)<jats:sub>3<\/jats:sub>] (CORM\u20103) with histidine residues exposed on the surface of proteins, spontaneously release CO in aqueous solution, cells, and mice. CO release was detected by mass spectrometry (MS) and confocal microscopy using a CO\u2010responsive turn\u2010on fluorescent probe. These findings support our hypothesis that plasma proteins act as CO carriers after in\u2005vivo administration of CORM\u20103. CO released from a synthetic bovine serum albumin (BSA)\u2013Ru<jats:sup>II<\/jats:sup>(CO)<jats:sub>2<\/jats:sub> complex leads to downregulation of the cytokines interleukin (IL)\u20106, IL\u201010, and tumor necrosis factor (TNF)\u2010\u03b1 in cancer cells. Finally, administration of BSA\u2013Ru<jats:sup>II<\/jats:sup>(CO)<jats:sub>2<\/jats:sub> in mice bearing a colon carcinoma tumor results in enhanced CO accumulation at the tumor. Our data suggest the use of Ru<jats:sup>II<\/jats:sup>(CO)<jats:sub>2<\/jats:sub>\u2013protein complexes as viable alternatives for the safe and spatially controlled delivery of therapeutic CO in\u2005vivo.<\/jats:p>","DOI":"10.1002\/anie.201409344","type":"journal-article","created":{"date-parts":[[2014,12,7]],"date-time":"2014-12-07T15:17:09Z","timestamp":1417965429000},"page":"1172-1175","source":"Crossref","is-referenced-by-count":132,"title":["Spontaneous CO Release from Ru<sup>II<\/sup>(CO)<sub>2<\/sub>\u2013Protein Complexes in Aqueous Solution, Cells, and Mice"],"prefix":"10.1002","volume":"54","author":[{"given":"Miguel","family":"Chaves\u2010Ferreira","sequence":"first","affiliation":[]},{"given":"In\u00eas S.","family":"Albuquerque","sequence":"additional","affiliation":[]},{"given":"Dijana","family":"Matak\u2010Vinkovic","sequence":"additional","affiliation":[]},{"given":"Ana C.","family":"Coelho","sequence":"additional","affiliation":[]},{"given":"Sandra M.","family":"Carvalho","sequence":"additional","affiliation":[]},{"given":"L\u00edgia M.","family":"Saraiva","sequence":"additional","affiliation":[]},{"given":"Carlos C.","family":"Rom\u00e3o","sequence":"additional","affiliation":[]},{"given":"Gon\u00e7alo J. 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