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Tripodal boronate complexes featuring reversible covalent bonds were designed to accommodate a cytotoxic drug (bortezomib), poly(ethylene glycol) (Peg) chains, and folate targeting units. The B\u2010complex core was assembled in one step, proved stable under biocompatible conditions, namely, in human plasma (half\u2010life up to 60\u2005h), and underwent disassembly in the presence of glutathione (GSH). Stimulus\u2010responsive intracellular cargo delivery was confirmed by confocal fluorescence microscopy, and a mechanism for GSH\u2010induced B\u2010complex hydrolysis was proposed on the basis of mass spectrometry and DFT calculations. This platform enabled the modular construction of multivalent conjugates with high selectivity for folate\u2010positive MDA\u2010MB\u2010231 cancer cells and IC<jats:sub>50<\/jats:sub> values in the nanomolar range.<\/jats:p>","DOI":"10.1002\/anie.201703492","type":"journal-article","created":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T14:30:39Z","timestamp":1496932239000},"page":"9346-9350","source":"Crossref","is-referenced-by-count":43,"title":["Modular Assembly of Reversible Multivalent Cancer\u2010Cell\u2010Targeting Drug Conjugates"],"prefix":"10.1002","volume":"56","author":[{"given":"F\u00e1bio M. 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Rovisco Pais 1 1049-001 Lisboa Portugal"}]},{"given":"Helena F.","family":"Florindo","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa) Faculty of Pharmacy Universidade de Lisboa  Lisbon Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7698-630X","authenticated-orcid":false,"given":"Pedro M. 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