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A literature survey over the last decade reveals steady growth in the stability information available. However, it also uncovers two significant problems that hinder proper data comparison: 1)\u2005the use of different stability assays, and 2)\u2005the differences in how stability information is reported. In this Viewpoint, we present results from a database meta\u2010analysis as well as concerns about the stability assessments published so far. We also suggest guidelines for a proper discussion between experts in the field on how to improve data readability so that peptide stability, an often\u2010missing parameter in older literature, is adequately reported to take maximum advantage of it.<\/jats:p>","DOI":"10.1002\/anie.202006372","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T10:34:10Z","timestamp":1605609250000},"page":"1686-1688","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["The Challenge of Peptide Proteolytic Stability Studies: Scarce Data, Difficult Readability, and the Need for Harmonization"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0938-9038","authenticated-orcid":false,"given":"Marco","family":"Cavaco","sequence":"first","affiliation":[{"name":"Department of Biochemistry Instituto de Medicina Molecular Faculdade de Medicina Universidade de Lisboa  Av. Prof Egas Moniz 1649-028 Lisboa Portugal"},{"name":"Proteomics and Protein Chemistry Unit Department of Experimental and Health Sciences Pompeu Fabra University  Dr Aiguader 88, Barcelona Biomedical Research Park 08003 Barcelona Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6317-6666","authenticated-orcid":false,"given":"David","family":"Andreu","sequence":"additional","affiliation":[{"name":"Proteomics and Protein Chemistry Unit Department of Experimental and Health Sciences Pompeu Fabra University  Dr Aiguader 88, Barcelona Biomedical Research Park 08003 Barcelona Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7891-7562","authenticated-orcid":false,"given":"Miguel A. R. B.","family":"Castanho","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Instituto de Medicina Molecular Faculdade de Medicina Universidade de Lisboa  Av. 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