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Whilst identifying small molecules that bind to specific RNA regions is the first step, the abundance of non\u2010functional RNA segments renders many interactions biologically inert. Consequently, small molecule binding does not necessarily meet stringent criteria for clinical translation, calling for solutions to push the field forward. Converting RNA\u2010binders into RNA\u2010degraders presents a promising avenue to enhance RNA\u2010targeting. This mini\u2010review outlines strategies and exemplars wherein simple small molecule RNA binders are reprogrammed into active degraders through the linkage of functional groups. These approaches encompass mechanisms that induce degradation via endogenous enzymes, termed RIBOTACs, as well as those with functional moieties acting autonomously to degrade RNA. 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