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The site\u2010 and stereoselective modification of native sugars is a definite goal of glycochemistry research. Recent efforts to bypass the need for protecting groups, leveraging selective activation through photochemical mechanisms for site\u2010selective C\u2212C bond formation from native sugars, are likely to largely impact all glycochemistry\u2010related areas. Davis, Koh, and co\u2010workers have recently presented their use of photocatalysis to develop a \u201ccap and glycosylate\u201d approach for the site\u2010 and stereoselective <jats:italic>C<\/jats:italic>\u2010glycosylation of native sugars. A modernized direct radical functionalization of in situ formed thioglycoside using photocatalysis was used in the synthetic manipulation of unprotected carbohydrates. This allowed reaching complex saccharides, and post\u2010translational modification of proteins.<\/jats:p>","DOI":"10.1002\/anie.202414424","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T05:00:34Z","timestamp":1727758834000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Light\u2010Driven Site\u2010Selective Glycosylation of Native Carbohydrates"],"prefix":"10.1002","volume":"63","author":[{"given":"Jo\u00e3o A.","family":"Pacheco","sequence":"first","affiliation":[{"name":"LAQV REQUIMTE Department of Chemistry University of Aveiro  3810-193 Aveiro Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2414-9064","authenticated-orcid":false,"given":"Nuno R.","family":"Candeias","sequence":"additional","affiliation":[{"name":"LAQV REQUIMTE Department of Chemistry University of Aveiro  3810-193 Aveiro Portugal"},{"name":"Faculty of Engineering and Natural Sciences Tampere University  Korkeakoulunkatu 8 33101 Tampere Finland"}]}],"member":"311","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"e_1_2_3_1_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00368C"},{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00234"},{"key":"e_1_2_3_3_1","unstructured":"\u00a0"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac8555"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.202300425"},{"key":"e_1_2_3_6_1","unstructured":"\u00a0"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00442"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.2c00892"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.checat.2023.100891"},{"key":"e_1_2_3_10_1","unstructured":"\u00a0"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b01531"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.1c01718"},{"key":"e_1_2_3_13_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7CC01416C"},{"key":"e_1_2_3_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c10963"},{"key":"e_1_2_3_15_1","unstructured":"\u00a0"},{"key":"e_1_2_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202305138"},{"key":"e_1_2_3_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.3c00374"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44160-022-00162-w"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.3c00833"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CC02361C"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44160-022-00214-1"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0QO01414A"},{"key":"e_1_2_3_23_1","unstructured":"\u00a0"},{"key":"e_1_2_3_24_2","doi-asserted-by":"publisher","DOI":"10.1039\/D1OB00311A"},{"key":"e_1_2_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2016.06.106"},{"key":"e_1_2_3_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07548-0"},{"key":"e_1_2_3_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2020.108197"},{"key":"e_1_2_3_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-021-00324-y"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202414424","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T07:31:27Z","timestamp":1759303887000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202414424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,6]]},"references-count":28,"journal-issue":{"issue":"50","published-print":{"date-parts":[[2024,12,9]]}},"alternative-id":["10.1002\/anie.202414424"],"URL":"https:\/\/doi.org\/10.1002\/anie.202414424","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"type":"print","value":"1433-7851"},{"type":"electronic","value":"1521-3773"}],"subject":[],"published":{"date-parts":[[2024,11,6]]},"assertion":[{"value":"2024-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202414424"}}