{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:52:49Z","timestamp":1791183169430,"version":"4.1.0"},"reference-count":131,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Benzisoxazoles are pivotal heterocyclic scaffolds that have emerged as focal points in both synthetic and medicinal chemistry due to their broad synthetic applications and a wide spectrum of pharmacological properties. Their unique structural framework, along with the presence of an oxygen\u2013nitrogen bond within a fused bicyclic ring system, confers remarkable physicochemical and biological properties, including anticancer, antibacterial, antifungal, antiviral, anti\u2010inflammatory and diuretic activities. Appropriately constructed benzisoxazole scaffolds display remarkable potential to interact with a broad range of biological targets, thereby offering significant opportunities for the development of novel therapeutic agents with diverse mechanisms of action. Chemists have been intrigued by the fascinating properties of benzisoxazoles, and extensive scientific studies have been carried out to integrate the benzisoxazole scaffold into various bioactive compounds, including complex molecular frameworks. The past few years have witnessed tremendous progress in the development of various multicomponent one\u2010pot synthetic strategies, including transition\u2010metal catalysis, metal\u2010free cyclization and microwave\u2010assisted synthesis for diversely substituted benzisoxazole derivatives. This review highlights recent advancements in the synthetic chemistry of functionalized benzisoxazoles, including marketed drugs and agents in clinical trials. Furthermore, recent developments in the medicinal chemistry of benzisoxazole derivatives as anticancer agents, encompassing their mechanistic aspects, structure\u2010activity relationships, and in silico studies, have been compiled. Drawing on the literature, the authors aim to provide a broad perspective and valuable insights for researchers, thereby inspiring and accelerating the development of novel benzisoxazole\u2010appended anticancer therapeutics with significant biological implications.<\/jats:p>","DOI":"10.1002\/ardp.70340","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:33:03Z","timestamp":1791181983000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Functionalized Benzisoxazoles: Recent Developments in Diversified Synthetic Strategies and Cytotoxic Potential"],"prefix":"10.1002","volume":"359","author":[{"given":"Shibangi","family":"Bhattacharjee","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences and Natural Products Central University of Punjab Bathinda Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayanita","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Natural Products Central University of Punjab Bathinda Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4202-111X","authenticated-orcid":false,"given":"Rajesh","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Natural Products Central University of Punjab Bathinda Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2677-0922","authenticated-orcid":false,"given":"Kamya","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry and Analysis ISF College of Pharmacy Moga Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4004-6241","authenticated-orcid":false,"given":"Vikramdeep","family":"Monga","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Natural Products Central University of Punjab Bathinda Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2021.129982","article-title":"An Insight Into the Medicinal Perspective of Synthetic Analogs of Imidazole","volume":"1232","author":"Rulhania S.","year":"2021","journal-title":"Journal of Molecular Structure"},{"issue":"2","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s41061-025-00502-2","article-title":"Applications of Bridgehead Heterocycles in Drug Design and Medicinal Chemistry","volume":"383","author":"Di Martino S.","year":"2025","journal-title":"Topics in Current Chemistry"},{"issue":"6","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"5219","DOI":"10.1007\/s11030-025-11110-z","article-title":"Click Chemistry: An Overview and Recent Updates in Medicinal Chemistry Attributes of Click\u2010Derived Heterocycles","volume":"29","author":"Bishnoi P.","year":"2025","journal-title":"Molecular Diversity"},{"issue":"3","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.bmcl.2007.12.023","article-title":"Design, Synthesis, and in Vitro Antitumor Activity of New 1,4\u2010Diarylimidazole\u20102\u2010Ones and Their 2\u2010Thione Analogues","volume":"18","author":"Congiu C.","year":"2008","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"issue":"2","key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/head.12769","article-title":"The Pharmacology of Indomethacin","volume":"56","author":"Lucas S.","year":"2016","journal-title":"Headache: The Journal of Head and Face Pain"},{"issue":"1","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1080\/14756366.2021.1901089","article-title":"Design, Synthesis, Anticancer Evaluation, and Molecular Modelling Studies of Novel Tolmetin Derivatives as Potential VEGFR\u20102 Inhibitors and Apoptosis Inducers","volume":"36","author":"Kassab A. 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