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The stability in aqueous media, <jats:italic>in\u2005vitro<\/jats:italic> cytotoxicity in a set of cancer cell lines (MCF7, PC3 and A2780\/A2780cisR) along with the cellular uptake are evaluated. Stability tests suggest hydrolysis of the ester within 8\u2005h, which might lead to deactivation. Furthermore, the <jats:italic>bis<\/jats:italic>\u2010NHC system shows a sufficient stability against cysteine and the thiol containing peptide GSH. The benzyl ester and amide show the highest activity comparable to the benchmark compound cisplatin, with the ester only displaying a slightly lower cytotoxicity than the amide. A cellular uptake study revealed that the benzyl ester and the amide could have different intracellular distribution profiles but both complexes induce perturbations of the cellular physiological processes. The simple modifiability and high stability of the complexes provides a promising system for upcoming post modifications to enable targeted cancer therapy.<\/jats:p>","DOI":"10.1002\/asia.202000620","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T07:20:45Z","timestamp":1593242445000},"page":"2754-2762","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Antiproliferative Activity of Functionalized Histidine\u2010derived Au(I) <i>bis<\/i>\u2010NHC Complexes for Bioconjugation"],"prefix":"10.1002","volume":"15","author":[{"given":"Christian H. 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