{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:09:57Z","timestamp":1767665397188},"reference-count":54,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2010,8,27]],"date-time":"2010-08-27T00:00:00Z","timestamp":1282867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioEssays"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clonal disease is often regarded as almost synonymous with cancer. However, it is becoming increasingly clear that our bodies harbor numerous mutant clones that are not tumors, and mostly give rise to no disease at all. Here we discuss three somatic mutations arising within the hematopoietic system: <jats:italic>BCR\u2010ABL<\/jats:italic>, characteristic of chronic myeloid leukemia; mutations of the <jats:italic>PIG\u2010A<\/jats:italic> gene, characteristic of paroxysmal nocturnal hemoglobinuria; the V617F mutation in the <jats:italic>JAK2<\/jats:italic> gene, characteristic of myeloproliferative diseases. The population frequencies of these three blood disorders fit well with a hierarchical model of hematopoiesis. The fate of any mutant clone will depend on the target cell and on the fitness advantage, if any, that the mutation confers on the cell. In general, we can expect that only a mutation in a hematopoietic stem cell will give long\u2010term disease; the same mutation taking place in a cell located more downstream may produce just a ripple in the hematopoietic ocean. <\/jats:p>","DOI":"10.1002\/bies.201000025","type":"journal-article","created":{"date-parts":[[2010,8,30]],"date-time":"2010-08-30T19:35:52Z","timestamp":1283196952000},"page":"1003-1008","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Somatic mutations and the hierarchy of hematopoiesis"],"prefix":"10.1002","volume":"32","author":[{"given":"Arne","family":"Traulsen","sequence":"first","affiliation":[]},{"given":"Jorge M.","family":"Pacheco","sequence":"additional","affiliation":[]},{"given":"Lucio","family":"Luzzatto","sequence":"additional","affiliation":[]},{"given":"David","family":"Dingli","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2010,8,27]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.69.1.497"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1198"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2009.12.004"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/255197a0"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81683-9"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1087"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-6544"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/4687"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.9.3362"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.9.5209"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2005.07.001"},{"key":"e_1_2_10_13_2","doi-asserted-by":"crossref","unstructured":"VainchenkerW ConstantinescuSN.2005. A Unique Activating Mutation in JAK2 (V617F) Is at the Origin of Polycythemia Vera and Allows a New Classification of Myeloproliferative Diseases.Hematology Am Soc Hematol Educ Program:195\u2013200.","DOI":"10.1182\/asheducation-2005.1.195"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2210"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103750"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196406182702506"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196406252702608"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.2307\/3571667"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112140"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000002"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.2.157"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000345"},{"key":"e_1_2_10_23_2","first-page":"1068","article-title":"Routes to repopulation\u2013a unification of the stochastic model and separation of stem\u2010cell subpopulations","volume":"8","author":"Gordon MY","year":"1994","journal-title":"Leukemia"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0296-190"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0427"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.77.021915"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0802749105"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.3816\/CLK.2008.n.017"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.015271"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.6.4.3853"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1006\/bulm.2002.0305"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.6.17.4649"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611179104"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.rpd.a032065"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00296144"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1159\/000131309"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/243290a0"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20006"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2009.04.003"},{"key":"e_1_2_10_40_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2406902"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81850-4"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1994.tb06754.x"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-01-0256"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90068-X"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601462103"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-02-002030"},{"key":"e_1_2_10_47_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-134858"},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.03.023"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.2307\/j.ctvjghw98"},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-009472"},{"key":"e_1_2_10_51_2","first-page":"111","article-title":"The JAK2(V617F) tyrosine kinase mutation in blood donors with upper\u2010limit haematocrit levels","volume":"7","author":"Tagariello G","year":"2009","journal-title":"Blood Transfus"},{"key":"e_1_2_10_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2004.10.015"},{"key":"e_1_2_10_53_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040258"},{"key":"e_1_2_10_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04980"},{"key":"e_1_2_10_55_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2535419100"}],"container-title":["BioEssays"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbies.201000025","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bies.201000025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T05:36:29Z","timestamp":1697607389000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bies.201000025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,27]]},"references-count":54,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["10.1002\/bies.201000025"],"URL":"https:\/\/doi.org\/10.1002\/bies.201000025","archive":["Portico"],"relation":{},"ISSN":["0265-9247","1521-1878"],"issn-type":[{"value":"0265-9247","type":"print"},{"value":"1521-1878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,27]]},"assertion":[{"value":"2010-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-07-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-08-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}