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This might guarantee the reliability of red colorations as individual quality signals independent of production costs. We hypothesize that the ornament type (feathers vs. bare parts) and production costs (probably CYP2J19 activity compromising vital functions) could have promoted tissue\u2010specific gene relocation. We review current avian tissue\u2010specific <jats:italic>CYP2J19<\/jats:italic> expression data. Among the ten red\u2010billed species showing <jats:italic>CYP2J19<\/jats:italic> bill expression, only one showed strong hepatic expression. Moreover, a phylogenetically\u2010controlled analysis of 25 red\u2010colored species shows that those producing red bare parts are less likely to have strong hepatic <jats:italic>CYP2J19<\/jats:italic> expression than species with only red plumages. Thus, both production costs and shared pathways might have contributed to the evolution of red signals.<\/jats:p>","DOI":"10.1002\/bies.202200037","type":"journal-article","created":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T10:44:59Z","timestamp":1665312299000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Relocation to avoid costs: A hypothesis on red carotenoid\u2010based signals based on recent <i>CYP2J19<\/i> gene expression data"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4765-551X","authenticated-orcid":false,"given":"Carlos","family":"Alonso\u2010Alvarez","sequence":"first","affiliation":[{"name":"Department of Evolutionary Ecology, National Museum of Natural Sciences \u2013 CSIC. 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