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Commonly, it is of interest to study the association between them. Joint modeling approaches of a single longitudinal outcome and survival process have recently gained increasing attention from both frequentist and Bayesian perspective. However, in many studies several longitudinal biomarkers are of interest and instead of selecting one single biomarker, the relationships between all these outcomes and their association with survival needs to be investigated. Our motivating study comes from Peritoneal Dialysis Programme in Nephrology research from Nephrology Unit, CHP (Hospital de Santo Ant\u00f3nio), Porto, Portugal in which the interest relies on the possible association between various biomarkers (calcium, phosphate, parathormone, and creatinine) and the patients' survival. To this aim, we propose a two\u2010stage model\u2010based approach for multivariate longitudinal and survival data that allowed us to study such complex association structure. The multivariate model suggested in this paper provided new insights in the area of nephrology research showing valid results in comparison with those models studying each longitudinal biomarker with survival separately.<\/jats:p>","DOI":"10.1002\/bimj.201600244","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T11:55:39Z","timestamp":1510746939000},"page":"1204-1220","source":"Crossref","is-referenced-by-count":9,"title":["Two\u2010stage model for multivariate longitudinal and survival data with application to nephrology research"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9725-7202","authenticated-orcid":false,"given":"Ipek","family":"Guler","sequence":"first","affiliation":[{"name":"Center for Research in Molecular Medicine and Chronic Diseases (CiMUS) University of Santiago de Compostela 15782 Santiago de Compostela A Coruna Spain"}]},{"given":"Christel","family":"Faes","sequence":"additional","affiliation":[{"name":"I\u2010Biostat Hasselt University BE3590 Diepenbeek Belgium"}]},{"given":"Carmen","family":"Cadarso\u2010Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Center for Research in Molecular Medicine and Chronic Diseases (CiMUS) University of Santiago de Compostela 15782 Santiago de Compostela A Coruna Spain"}]},{"given":"Laetitia","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias Biom\u00e9dicas Abel Salazar Universidade do Porto Porto Portugal"},{"name":"CINTESIS, Instituto de Ciencias Biom\u00e9dicas Abel Salazar Universidade do Porto Porto Portugal"}]},{"given":"Anabela","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias Biom\u00e9dicas Abel Salazar Universidade do Porto Porto Portugal"},{"name":"Centro Hospitalar do Porto Hospital Geral de Santo Ant\u00f3nio Porto Portugal"}]},{"given":"Denisa","family":"Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias Biom\u00e9dicas Abel Salazar Universidade do Porto Porto Portugal"},{"name":"EPIUnit, Instituto de Sa\u00fade P\u00fablica Universidade do Porto Porto Portugal"}]}],"member":"311","published-online":{"date-parts":[[2017,11,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1541-0420.2009.01324_1.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2005.030929.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04260413"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life\u2010tables (with discussion)","volume":"34","author":"Cox D.","year":"1972","journal-title":"Journal of the Royal Statistical Society"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1541-0420.2007.00896.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1541-0420.2007.00952.x"},{"key":"e_1_2_10_8_1","unstructured":"Guler I. 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