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In this work, a dodecapeptide phage\u2010display library was panned against retrovirus like particles expressing the envelope protein Ampho4070A (VLPs\u2010AMPHO) and VLPs without the target protein, used as a negative control (VLPs). A depletion\/selection panning protocol was successfully used to deal with the structural complexity of the target, and a total of three distinct peptide sequences displaying preferential binding towards VLPs\u2010AMPHO were found. Peptide 3 (CAAALAKPHTENHLLT), which appeared as one lead candidate, was synthesized and immobilized onto two purification matrices, cross\u2010linked agarose and magnetic particles. 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