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More recently, with the emergence of rapid\u2010prototyping techniques for fabrication of microfluidic structures with intricate designs, ATPE gained an expanded range of applications utilizing physical phenomena occurring exclusively at the microscale. Today, research is being carried simultaneously in two different volume ranges, mL\u2010scale (microtubes) and nL\u2010scale (microchannels). The objective of this review is to give insight into the state of the art at both microtube and microchannel\u2010scale and to analyze whether miniaturization is currently a competing or divergent technology in a field of applications including bioseparation, bioanalytics, enhanced fermentation processes, catalysis, high\u2010throughput screening and physical\/chemical compartmentalization. From our perspective, both approaches are worthy of investigation and, depending on the application, it is likely that either (i) one of the approaches will eventually become obsolete in particular research areas such as purification at the preparative scale or high\u2010throughput screening applications; or (ii) both approaches will function as complementing techniques within the bioanalytics field.<\/jats:p>","DOI":"10.1002\/biot.201600356","type":"journal-article","created":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T05:53:17Z","timestamp":1473832397000},"page":"1498-1512","source":"Crossref","is-referenced-by-count":25,"title":["Miniaturization of aqueous two\u2010phase extraction for biological applications: From micro\u2010tubes to microchannels"],"prefix":"10.1002","volume":"11","author":[{"given":"Ruben R. 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