{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:11:50Z","timestamp":1777590710453,"version":"3.51.4"},"reference-count":174,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,28]],"date-time":"2017-12-28T00:00:00Z","timestamp":1514419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/52000\/2012"],"award-info":[{"award-number":["SFRH\/BD\/52000\/2012"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/52014\/2012"],"award-info":[{"award-number":["SFRH\/BD\/52014\/2012"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/BIO\/04565\/2013"],"award-info":[{"award-number":["UID\/BIO\/04565\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biotechnology Journal"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:label\/><jats:p>The adult bone marrow (BM) niche is a complex entity where a homeostatic hematopoietic system is maintained through a dynamic crosstalk between different cellular and non\u2010cellular players. Signaling mechanisms triggered by cell\u2010cell, cell\u2010extracellular matrix (ECM), cell\u2010cytokine interactions, and local microenvironment parameters are involved in controlling quiescence, self\u2010renewal, differentiation, and migration of hematopoietic stem\/progenitor cells (HSPC). A promising strategy to more efficiently expand HSPC numbers and tune their properties ex vivo is to mimic the hematopoietic niche through integration of adjuvant stromal cells, soluble cues, and\/or biomaterial\u2010based approaches in HSPC culture systems. Particularly, mesenchymal stem\/stromal cells (MSC), through their paracrine activity or direct contact with HSPC, are thought to be a relevant niche player, positioning HSPC\u2010MSC co\u2010culture as a valuable platform to support the ex vivo expansion of hematopoietic progenitors. To improve the clinical outcome of hematopoietic cell transplantation (HCT), namely when the available HSPC are present in a limited number such is the case of HSPC collected from umbilical cord blood (UCB), ex vivo expansion of HSPC is required without eliminating the long\u2010term repopulating capacity of more primitive HSC. Here, we will focus on depicting the characteristics of co\u2010culture systems, as well as other bioengineering approaches to improve the functionality of HSPC ex vivo.<\/jats:p><\/jats:sec>","DOI":"10.1002\/biot.201700088","type":"journal-article","created":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T02:07:26Z","timestamp":1511748446000},"source":"Crossref","is-referenced-by-count":30,"title":["Hematopoietic Niche \u2013 Exploring Biomimetic Cues to Improve the Functionality of Hematopoietic Stem\/Progenitor Cells"],"prefix":"10.1002","volume":"13","author":[{"given":"Marta H. G.","family":"Costa","sequence":"first","affiliation":[{"name":"Department of Bioengineering and iBB\u2010Institute for Bioengineering and Biosciences Instituto Superior T\u00e9cnico Universidade de Lisboa Lisboa Portugal"}]},{"given":"Ant\u00f3nio M.","family":"de Soure","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and iBB\u2010Institute for Bioengineering and Biosciences Instituto Superior T\u00e9cnico Universidade de Lisboa Lisboa Portugal"}]},{"given":"Joaquim M. S.","family":"Cabral","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and iBB\u2010Institute for Bioengineering and Biosciences Instituto Superior T\u00e9cnico Universidade de Lisboa Lisboa Portugal"},{"name":"The Discoveries Centre for Regenerative and Precision Medicine Lisbon Campus Instituto Superior T\u00e9cnico Universidade de Lisboa Lisboa Portugal"}]},{"given":"Frederico Castelo","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and iBB\u2010Institute for Bioengineering and Biosciences Instituto Superior T\u00e9cnico Universidade de Lisboa Lisboa Portugal"},{"name":"The Discoveries Centre for Regenerative and Precision Medicine Lisbon Campus Instituto Superior T\u00e9cnico Universidade de Lisboa Lisboa Portugal"}]},{"given":"Cl\u00e1udia L.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and iBB\u2010Institute for Bioengineering and Biosciences Instituto Superior T\u00e9cnico Universidade de Lisboa Lisboa Portugal"},{"name":"The Discoveries Centre for Regenerative and Precision Medicine Lisbon Campus Instituto Superior T\u00e9cnico Universidade de Lisboa Lisboa Portugal"}]}],"member":"311","published-online":{"date-parts":[[2017,12,28]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.2307\/3570877"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.22.8736"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-07-533588"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195709122571102"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(68)92673-1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2008.56"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-322214"},{"key":"e_1_2_10_8_1","first-page":"55","volume":"2007","author":"Barker J. N.","year":"2007","journal-title":"ASH Educ. Program Book"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006223422501"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1182\/blood.V88.3.795.795","volume":"88","author":"Wagner J. E.","year":"1996","journal-title":"Blood"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0294"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-07-2717"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/b922637k"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.1741"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1207285"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(02)00805-6"},{"key":"e_1_2_10_17_1","first-page":"7","volume":"4","author":"Schofield R.","year":"1978","journal-title":"Blood Cells"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02040"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-08-041384"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.05.026"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21908"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2010.06.002"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13034"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.1731"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.22-5-716"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0029"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.2174\/157339708785133479"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.9.1365"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.08.017"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.3.599"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199409073776"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.5.1289"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.07.004"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.10.016"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3300480"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.135921"},{"key":"e_1_2_10_37_1","first-page":"1","volume":"6","author":"Zoller M.","year":"2015","journal-title":"Front. Immunol"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7231567"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2011.02.011"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2006.15.815"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.22-3-253"},{"key":"e_1_2_10_42_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/term.226","volume":"4","author":"da Silva C. L.","year":"2009","journal-title":"J. Tissue Eng. Regen. Med"},{"key":"e_1_2_10_43_1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1182\/blood.V91.1.111","volume":"91","author":"Breems D. A.","year":"1998","journal-title":"Blood"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.03.041"},{"key":"e_1_2_10_45_1","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1182\/blood.V79.11.2821.2821","volume":"79","author":"Verfaillie C. M.","year":"1992","journal-title":"Blood"},{"key":"e_1_2_10_46_1","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1182\/blood.V95.3.846.003k31_846_854","volume":"95","author":"Jiang Y.","year":"2000","journal-title":"Blood"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1089\/152581600750062264"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-11-4422"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2004-0120"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2007.10.008"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.08.025"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0280"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2955"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2015.04.011"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03799.x"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(99)00031-4"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-09-3079"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0188-4409(01)00368-X"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4889(02)00324-5"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2080"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0216167"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2015.10.004"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1191536"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2009.09.001"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2984"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.17421911"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-016-1962-x"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215549804600311"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.09.140"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-6041\/6\/5\/055011"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/326403a0"},{"key":"e_1_2_10_72_1","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1089\/ten.tea.2008.0348","volume":"15","author":"Bladergroen B. A.","year":"2008","journal-title":"Tissue Eng. Part A"},{"key":"e_1_2_10_73_1","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1634\/stemcells.2006-0513","volume":"25","author":"Gottschling S.","year":"2006","journal-title":"Stem Cells"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.2.529"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1258\/ebm.2011.011075"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101688"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2009.00776.x"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09262"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(02)00820-2"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-01-0433"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2011.06.006"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2010.01419.x"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2008.12.005"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2184.1970.tb00347.x"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/1478-811X-9-12"},{"key":"e_1_2_10_86_1","doi-asserted-by":"crossref","first-page":"3620","DOI":"10.1182\/blood.V95.11.3620","volume":"95","author":"Almeida\u2010Porada G.","year":"2000","journal-title":"Blood"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/968213"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.3109\/14653240903180076"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2005.03.017"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1040910303"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvn082"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-07-099622"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0022"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1008117107"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2013.09.004"},{"key":"e_1_2_10_96_1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1089\/ten.tea.2009.0255","volume":"16","author":"He J.","year":"2009","journal-title":"Tissue Eng. Part A"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201200169"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2012.02.018"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1499"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.04.079"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2013.05.001"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-011-1212-8"},{"key":"e_1_2_10_103_1","first-page":"2720","volume":"51","author":"Foty R.","year":"2011","journal-title":"J. Vis. Exp"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001565"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep03462"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2016.0329"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11626-997-0064-8"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1594.2002.06836.x"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009093"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2011.0159"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4148093"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.72.4.837"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20122252"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2001.5210"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.06.029"},{"key":"e_1_2_10_116_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1089\/ten.tec.2011.0706","volume":"19","author":"Ventura Ferreira M. S.","year":"2013","journal-title":"Tissue Eng. Part C Methods"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10616-010-9297-6"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2016.2712"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-016-0234-9"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.06.017"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsfs.2011.0033"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA13332G"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2015.0182"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.10.030"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12103"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2011.01324.x"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.07.033"},{"key":"e_1_2_10_128_1","first-page":"334","volume":"8","author":"Song K.","year":"2011","journal-title":"Tissue Eng. Regen Med"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.050500"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.10.038"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1039\/B815718A"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.11.034"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep31951"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-015-2348-8"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.3109\/08977194.2015.1088534"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-7799(03)00076-3"},{"key":"e_1_2_10_137_1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/978-94-011-4786-6_14","author":"De Le\u00f3n A.","year":"1998","journal-title":"Cell Cult. Eng"},{"key":"e_1_2_10_138_1","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1182\/blood.V82.2.378.378","volume":"82","author":"Koller M. R.","year":"1993","journal-title":"Blood"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008085932764"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1021\/bp00020a600"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2008.09.009"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2011.0134"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-08-595561"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.25485"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.31614"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04808-0"},{"key":"e_1_2_10_147_1","first-page":"1","author":"Sieber S.","year":"2017","journal-title":"J. Tissue Eng. Regen. Med"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2938"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.038836"},{"key":"e_1_2_10_150_1","first-page":"297","volume":"122","author":"Milano F.","year":"2013","journal-title":"Blood"},{"key":"e_1_2_10_151_1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1182\/blood.V124.21.46.46","volume":"124","author":"Milano F.","year":"2014","journal-title":"Blood"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2004.03.002"},{"key":"e_1_2_10_153_1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1182\/blood.V122.21.295.295","volume":"122","author":"Stiff P. J.","year":"2013","journal-title":"Blood"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI74556"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab2116"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2010.07.007"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.4.619"},{"key":"e_1_2_10_158_1","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1182\/blood.V94.3.923.415k08_923_931","volume":"94","author":"Kollet O.","year":"1999","journal-title":"Blood"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8583"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.19-4-313"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1080\/14653240410004916"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2005.10.002"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-122119"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2011.12.005"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1256337"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705258"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1159\/000108630"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.12.2161"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.3727\/000000007783465073"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-015-0194-y"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1179\/1607845412Y.0000000034"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2012.09.002"},{"key":"e_1_2_10_173_1","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1089\/scd.2010.0456","volume":"20","author":"Khoury M.","year":"2010","journal-title":"Stem Cells Dev"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.23019"}],"container-title":["Biotechnology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbiot.201700088","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/biot.201700088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:41:13Z","timestamp":1759938073000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/biot.201700088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,28]]},"references-count":174,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1002\/biot.201700088"],"URL":"https:\/\/doi.org\/10.1002\/biot.201700088","archive":["Portico"],"relation":{},"ISSN":["1860-6768","1860-7314"],"issn-type":[{"value":"1860-6768","type":"print"},{"value":"1860-7314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,28]]},"article-number":"1700088"}}