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Nevertheless, commonly employed manufacturing methods for gold\u2010based nanoparticles require long periods and laborious protocols that reduce cost\u2010effectiveness and scalability. Herein, a novel methodology was used for producing gold\u2010alginic acid nanohybrids (Au\u2010Alg\u2010NH) with photothermal capabilities. This was accomplished by promoting the in situ reduction and nucleation of gold ions throughout a matrix of alginic acid by using ascorbic acid. The results obtained reveal that the Au\u2010Alg\u2010NHs present a uniform size distribution and a spike\u2010like shape. Moreover, the nanomaterials were capable to mediate a temperature increase of \u224811\u00b0C in response to the irradiation with a near\u2010infrared region (NIR) laser (808\u00a0nm, 1.7\u00a0W cm<jats:sup>\u22122<\/jats:sup>). The in vitro assays showed that Au\u2010Alg\u2010NHs were able to perform a NIR light\u2010triggered ablation of cancer cells (MCF\u20107), being observed a reduction in the cell viability to \u224827%. Therefore, the results demonstrate that this novel methodology holds the potential for producing Au\u2010Alg\u2010NH with photothermal capacity and higher translatability to the clinical practice, namely for cancer therapy.<\/jats:p>","DOI":"10.1002\/biot.202300019","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T13:21:33Z","timestamp":1694697693000},"source":"Crossref","is-referenced-by-count":4,"title":["In situ formation of alginic acid\u2010gold nanohybrids for application in cancer photothermal therapy"],"prefix":"10.1002","volume":"19","author":[{"given":"Andr\u00e9 Q.","family":"Figueiredo","sequence":"first","affiliation":[{"name":"CICS\u2010UBI \u2013 Health Sciences Research Centre Universidade da Beira Interior  Covilh\u00e3 Portugal"}]},{"given":"Carolina F.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"CICS\u2010UBI \u2013 Health Sciences Research Centre Universidade da Beira Interior  Covilh\u00e3 Portugal"}]},{"given":"Natanael","family":"Fernandes","sequence":"additional","affiliation":[{"name":"CICS\u2010UBI \u2013 Health Sciences Research Centre Universidade da Beira Interior  Covilh\u00e3 Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0490-0095","authenticated-orcid":false,"given":"Il\u00eddio J.","family":"Correia","sequence":"additional","affiliation":[{"name":"CICS\u2010UBI \u2013 Health Sciences Research Centre Universidade da Beira Interior  Covilh\u00e3 Portugal"},{"name":"CIEPQPF \u2013 Departamento de Engenharia Qu\u00edmica Universidade de Coimbra  Coimbra Portugal"}]},{"given":"Andr\u00e9 F.","family":"Moreira","sequence":"additional","affiliation":[{"name":"CICS\u2010UBI \u2013 Health Sciences Research Centre Universidade da Beira Interior  Covilh\u00e3 Portugal"},{"name":"CPIRN\u2010UDI\/IPG \u2013 Centro de Potencial e Inova\u00e7\u00e3o em Recursos Naturais Unidade de Investiga\u00e7\u00e3o para o Desenvolvimento do Interior do Instituto 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