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Using micro\u2010structured ceramic tubes as \u201csubstrate,\u201d mycoponics provides mycelial cellular filaments with an air\u2010phase\/solid\u2010state, antimicrobial interface for cellular liquid nutrient media uptake. We show how antimicrobial biophysical size exclusion facilitates mycoponic \u201cpersistent\u2010filtration\u2010defense\u201d (PFD), experimentally confirmed using flow cytometry, and electron microscopic analysis of the interfacial ceramic pores (less than 300\u00a0nm). The antimicrobial mycoponic interface enabled development of a complete mycoponic nutrient medium, producing blue oyster mushrooms from liquid culture 2 weeks post inoculation. This completely eliminates grain\u2010spawn (2\u20134 weeks) and fruiting phase (2\u20134 weeks) times using granular substrate bags that require energy\/time\u2010intensive antimicrobial processing. Mycelial colonization times decreased by 9 days, while biomass increased (170%) with activated carbon inside the tubes. Mycoponic cultivation of Reishi mycoleather gloves demonstrates direct 3D\u2010mycomaterials, and we show how mycoponics enables advanced scientific imaging (thermal) and techniques, including mycelial exudate recovery for drug discovery. Mycoponics enables hybrid solid\u2010state, liquid culture for continuous bioproduction of mycelial pharmaceuticals, representing 18% of the global market. The efficiency and extended cultivation enabled by mycoponics will facilitate significant future advances in mycology and mycoengineering.<\/jats:p>","DOI":"10.1002\/biot.70184","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T09:29:31Z","timestamp":1770370171000},"source":"Crossref","is-referenced-by-count":0,"title":["Mycoponics: Controlled Bioproduction Utilizing Biophysical, Solid\u2010State, Liquid Nutrient Delivery"],"prefix":"10.1002","volume":"21","author":[{"given":"D. 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