{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:02:00Z","timestamp":1790326920319,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100016350","name":"Sichuan Provincial Administration of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["2024MS406"],"award-info":[{"award-number":["2024MS406"]}],"id":[{"id":"10.13039\/501100016350","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Osteoarthritis (OA) is a leading cause of pain and disability in older adults. Sleep disturbance and depressive symptoms are common and have been linked to multiple chronic conditions, yet how their co\u2010developing longitudinal patterns relate to OA onset remains unclear. We aimed to identify joint trajectories of sleep disturbance and depressive symptoms and examine their associations with incident OA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were drawn from the English Longitudinal Study of Ageing (ELSA), a nationally representative prospective cohort of community\u2010dwelling adults aged \u2265\u00a050 years. Sleep disturbance and depressive symptoms (CES\u2010D) assessed across three waves over eight years were modeled using group\u2010based multi\u2010trajectory modeling (GBMTM). OA incidence was defined as new\u2010onset OA between Wave 8 and Wave 9 among participants free of OA at Wave 8. Multivariable logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for sociodemographic factors, health behaviors, body mass index, and comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 3604 participants were included. Four joint trajectory groups were identified: persistently good sleep\/no depressive symptoms; persistently moderate sleep disturbance\/low depressive symptoms; persistently poor sleep\/moderate depressive symptoms; and persistently poor sleep\/persistently high depressive symptoms. Compared with the persistently good sleep\/no depressive symptoms group, the fully adjusted odds of incident OA were higher in the persistently poor sleep\/persistently high depressive symptoms group (OR\u00a0=\u00a02.85, 95% CI 1.90\u20134.28), the persistently poor sleep\/moderate depressive symptoms group (OR\u00a0=\u00a02.14, 95% CI 1.52\u20133.02), and the persistently moderate sleep disturbance\/low depressive symptoms group (OR\u00a0=\u00a01.56, 95% CI 1.20\u20132.03).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Long\u2010term co\u2010occurrence of sleep disturbance and depressive symptoms was associated with incident OA in middle\u2010aged and older adults. These patterns may help identify adults at elevated risk, but causal effects and the preventive value of sleep or depression interventions require confirmation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71788","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:08:35Z","timestamp":1790230115000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi\u2010Trajectories of Sleep Disturbance and Depressive Symptoms and Incident Osteoarthritis: Evidence From the English Longitudinal Study of Ageing"],"prefix":"10.1002","volume":"16","author":[{"given":"Shufang","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Tuina No.3 Affiliated Hospital of Chengdu University of Traditional Chinese Medicine (West District), Chengdu Pidu District Hospital of Traditional Chinese Medicine  Chengdu 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