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This extends the previously introduced labeling strategy of metal\u2010mediated <jats:italic>retro\u2010Diels\uf8ffAlder<\/jats:italic> reaction with HCp\u2010R dimers. We demonstrate that chemically active functionalities such as hydroxamic acids are not following this labeling strategy. Adopting the principle of replacing phenyl rings by [Re(CO)<jats:sub>3<\/jats:sub>(Cp)] entities, potent histone deacetylase (HDAC)\u2010inhibiting Re analogs of suberoylanlilide hydroxamic acid (SAHA; <jats:italic>N<\/jats:italic>\u2010hydroxy\u2010<jats:italic>N\u2032<\/jats:italic>\u2010phenyloctanediamide) were synthesized and characterized. Cytotoxic evaluation on different tumor cell lines revealed low <jats:italic>IC<\/jats:italic><jats:sub>50<\/jats:sub> values [\u03bc<jats:sc>M<\/jats:sc>] for these compounds, comparable to their purely organic congeners.<\/jats:p>","DOI":"10.1002\/cbdv.201200076","type":"journal-article","created":{"date-parts":[[2012,9,13]],"date-time":"2012-09-13T13:56:45Z","timestamp":1347544605000},"page":"1849-1866","source":"Crossref","is-referenced-by-count":31,"title":["The [(Cp)M(CO)<sub>3<\/sub>] (M=Re, <sup>99m<\/sup>Tc) Building Block for Imaging Agents and Bioinorganic Probes: Perspectives and Limitations"],"prefix":"10.1002","volume":"9","author":[{"given":"Daniel","family":"Can","sequence":"first","affiliation":[]},{"given":"Harmel W.","family":"Peindy\u2005N'Dongo","sequence":"additional","affiliation":[]},{"given":"Bernhard","family":"Spingler","sequence":"additional","affiliation":[]},{"given":"Paul","family":"Schmutz","sequence":"additional","affiliation":[]},{"given":"Paula","family":"Raposinho","sequence":"additional","affiliation":[]},{"given":"Isabel","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Roger","family":"Alberto","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2012,9,13]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"crossref","unstructured":"R.Alberto in \u2018Bioinorganic Medicinal Chemistry\u2019 Ed. 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