{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T22:55:24Z","timestamp":1754261724070},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T00:00:00Z","timestamp":1394755200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The chemical composition of the essential oil isolated from the aerial parts of <jats:italic>Melampodium divaricatum<\/jats:italic> (<jats:sc>Rich<\/jats:sc>.) DC. (Asteraceae) was characterized by GC\u2010FID and GC\/MS analyses. (<jats:italic>E<\/jats:italic>)\u2010Caryophyllene (56.0%), germacrene D (12.7%), and bicyclogermacrene (9.2%) were identified as the major oil components. The antimicrobial activity of the oil against seven standard strains of oral pathogens from the <jats:italic>American Type Culture Collection<\/jats:italic> (ATCC) was evaluated by determining minimum inhibitory concentrations (<jats:italic>MIC<\/jats:italic>s) using the microdilution method. <jats:italic>MIC<\/jats:italic> Values below 100\u2005\u03bcg\/ml were obtained against <jats:italic>Streptococcus sobrinus<\/jats:italic> (90\u2005\u03bcg\/ml), <jats:italic>Lactobacillus casei<\/jats:italic> (30\u2005\u03bcg\/ml), <jats:italic>S. mutans<\/jats:italic> (20\u2005\u03bcg\/ml), and <jats:italic>S. mitis<\/jats:italic> (18\u2005\u03bcg\/ml). In contrast, the <jats:italic>MIC<\/jats:italic> values of the major oil compound (<jats:italic>E<\/jats:italic>)\u2010caryophyllene were higher than 400\u2005\u03bcg\/ml against all pathogens, suggesting that the activity of the oil might depend on minor oil components and\/or on synergistic effects. The <jats:italic>M. divaricatum<\/jats:italic> essential oil is a promising agent to include in anticariogenic oral rinse formulations for the control of oral pathogens.<\/jats:p>","DOI":"10.1002\/cbdv.201300322","type":"journal-article","created":{"date-parts":[[2014,3,15]],"date-time":"2014-03-15T00:43:11Z","timestamp":1394844191000},"page":"438-444","source":"Crossref","is-referenced-by-count":14,"title":["Composition and Activity against Oral Pathogens of the Essential Oil of <i>Melampodium divaricatum<\/i> (<scp>Rich<\/scp>.) 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