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The available treatments are temporary, acting over short period of time. The main pathological hallmark of the disease includes cholinergic dysfunction, oxidative stress, accumulation of A\u03b2 fibrils and <jats:italic>tau<\/jats:italic> tangles. In context with the multi\u2010factorial nature of this disease, two different series of molecules were developed to hit the multifactorial disease targets. Mainly, the molecules were designed to inhibit the AChE and aggregation of A\u03b2, and also oxidative damage. Two novel series of TAC\u2010fenbufen\/menbutone conjugated molecules were designed, synthesized and bio\u2010assayed. All compounds showed inhibition capacity towards AChE, A\u03b2 aggregation and moderate to good radical scavenging capacity. Particularly, five TAC\u2010menbutone molecules showed improved AChE and A\u03b2 aggregation inhibition capacity compared to TAC\u2010fenbufen conjugated molecules. Overall, these novel series of molecules may be potential drug lead molecules in the treatment of AD.<\/jats:p>","DOI":"10.1002\/cbdv.202000083","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T23:26:39Z","timestamp":1610753199000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multi\u2010Targeting Tacrine Conjugates with Cholinesterase and Amyloid\u2010Beta Inhibitory Activities: New Anti\u2010Alzheimer's Agents"],"prefix":"10.1002","volume":"18","author":[{"given":"Asha","family":"Hiremathad","sequence":"first","affiliation":[{"name":"Organic and Medicinal Chemistry Laboratory, Center for Nano and Material Sciences Jain University, Jain Global Campus, Jakkasandra Post  Kanakapura Road Ramanagara District Karnataka 562112 India"},{"name":"Centro de Qu\u00edmica Estrutural and Departamento de Engenharia Qu\u00edmica, Instituto Superior T\u00e9cnico Universidade de Lisboa  Av. Rovisco Pais 1 1049-001 Lisboa Portugal"}]},{"given":"S\u00edlvia","family":"Chaves","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural and Departamento de Engenharia Qu\u00edmica, Instituto Superior T\u00e9cnico Universidade de Lisboa  Av. 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