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Its phenolic profile was determined using ultra\u2010high\u2010performance liquid chromatography coupled with a diode array detector and an electrospray mass spectrometer (UHPLC\u2010DAD\u2010ESI\/MS), which allowed the identification and quantification of 17 compounds, 1,5\u2010<jats:italic>O<\/jats:italic>\u2010caffeoylquinic acid being the most abundant. The cytotoxic activity was assessed against human gastric cancer (AGS) and human non\u2010small\u2010cell lung cancer (A549) cell lines, whereas ethanolic extract elicited nearly 60\u2009% and 40\u2009% viability loss toward AGS and A549 cancer cells, respectively. Results also showed that cell death is caspase\u2010independent and confirmed the involvement of RIPK1 and the necroptosis pathway in the toxicity induced by the <jats:italic>I. viscosa<\/jats:italic> extract. In addition, the ethanolic extract would not provoke morphological traits in the cancer cells. These findings suggest that <jats:italic>I. viscosa<\/jats:italic> can be a source of new antiproliferative drugs or used in preparation plant\u2010derived pharmaceuticals.<\/jats:p>","DOI":"10.1002\/cbdv.202200890","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T10:44:35Z","timestamp":1676371475000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["<i>Inula viscosa<\/i> (L.) Aiton Ethanolic Extract Inhibits the Growth of Human AGS and A549 Cancer Cell Lines"],"prefix":"10.1002","volume":"20","author":[{"given":"Habiba","family":"Rechek","sequence":"first","affiliation":[{"name":"Faculty of Sciences of Nature and Life Mohamed Cherif Messaadia University, Souk Ahras  41000 Souk-Ahras Algeria"},{"name":"Department of Biology of Organisms Faculty of Sciences of Nature and Life University of Batna 2  Mostefa Ben Boulaid 05078 Batna Algeria"},{"name":"LAQV-REQUIMTE &amp; Department of Chemistry University of Aveiro  3810-193 Aveiro Portugal"}]},{"given":"Ammar","family":"Haouat","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Valorisation des Ressources Naturelles Mol\u00e9cules Bioactives et Analyse Physicochimiques et Biologiques (VARENBIOMOL) Universit\u00e9 des Fr\u00e8res Mentouri  25000 Constantine Algeria"},{"name":"Department of Biology Faculty of Sciences of Nature and Life University of Oued Souf  39 000 Oued Souf Algeria"}]},{"given":"Kaouther","family":"Hamaidia","sequence":"additional","affiliation":[{"name":"Faculty of Sciences of Nature and Life Mohamed Cherif Messaadia University, Souk Ahras  41000 Souk-Ahras Algeria"},{"name":"Laboratory of Applied Animal Biology Badji Mokhtar University  23000 Annaba Algeria"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4249-7089","authenticated-orcid":false,"given":"Diana C. 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