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Moreover, their antioxidant, \u03b1\u2010glucosidase, acetylcholinesterase, and butyrylcholinesterase inhibitory activities were evaluated. The butan\u20101\u2010ol fraction revealed the highest total phenolic content and exhibited the highest antioxidant capacity. From the inhibitory enzyme evaluations, it should be highlighted the butan\u20101\u2010ol fraction inhibitory potential of \u0251\u2010glucosidase (the IC\n                    <jats:sub>50<\/jats:sub>\n                    =141.18\u00b14\u2005\u03bcg\/mL), which was better than the acarbose inhibitory effect (IC\n                    <jats:sub>50<\/jats:sub>\n                    =203.41\u00b11.07\u2005\u03bcg\/mL). The extracts\u2019 chemical profile analysis revealed several compounds, in which quercetin dimethyl ether, harmine and harmaline emerged as the major compounds. The different solvents used impacted\n                    <jats:italic>Peganum harmala<\/jats:italic>\n                    seed contents and biological responses. Statistical analysis showed a significant correlation between bioactive compounds and biological activities. Thus,\n                    <jats:italic>Peganum harmala<\/jats:italic>\n                    seeds could be a promising natural source of bioactive compounds at the crossroads of many human diseases, and its cultivation may be encouraged.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202401308","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T05:38:47Z","timestamp":1722231527000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Phytochemical Profile, Antioxidant, Anti\u2010Alzheimer, And \u03b1\u2010Glucosidase Inhibitory Effect Of Algerian\n                    <i>Peganum harmala<\/i>\n                    Seeds Extract"],"prefix":"10.1002","volume":"21","author":[{"given":"Hanane","family":"Benramdane","sequence":"first","affiliation":[{"name":"LAPSAB, Department of Biology University of Abou Bekr Belkaid  Tlemcen 13000 Algeria"},{"name":"LAQV-REQUIMTE, Department of Chemistry University of Aveiro  Aveiro 3810-193 Portugal"}]},{"given":"Nabila","family":"Benariba","sequence":"additional","affiliation":[{"name":"LAPSAB, Department of Biology University of Abou Bekr Belkaid  Tlemcen 13000 Algeria"}]},{"given":"Carlos F. M.","family":"Silva","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Department of Chemistry University of Aveiro  Aveiro 3810-193 Portugal"}]},{"given":"Marcelo D.","family":"Catarino","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Department of Chemistry University of Aveiro  Aveiro 3810-193 Portugal"}]},{"given":"Maria","family":"Bartolomeu","sequence":"additional","affiliation":[{"name":"CESAM, Department of Biology University of Aveiro  Aveiro 3810-193 Portugal"}]},{"given":"Zohra","family":"Fekhikher","sequence":"additional","affiliation":[{"name":"LAPSAB, Department of Biology University of Abou Bekr Belkaid  Tlemcen 13000 Algeria"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4249-7089","authenticated-orcid":false,"given":"Diana C. G. 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