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Among protein kinases (PKCs), PKC\u2010\u03b4 acts as a tumor suppressor in colon cancer and represents a valuable therapeutic target. Human serum albumin (HSA) is gaining attention as an efficient drug carrier, while\n                    <jats:italic>Plectranthus<\/jats:italic>\n                    spp. offers a rich source of bioactive compounds. One such molecule is 7\u03b1\u2010acetoxy\u20106\u03b2\u2010hydroxyroyleanone (Roy,\n                    <jats:bold>1<\/jats:bold>\n                    ), a cytotoxic abietane diterpenoid with modifiable hydroxyl groups, making it a promising scaffold for drug development. This study aimed to design a theoretical library of Roy\n                    <jats:bold>1<\/jats:bold>\n                    derivatives targeting PKC\u2010\u03b4. Hydroxyl groups at positions C6 and C12 were modified to explore interactions through molecular docking against the PKC\u2010\u03b4 regulatory domain (1PTR). Compound\n                    <jats:bold>16<\/jats:bold>\n                    emerged as the most promising candidate. Additionally, the binding of Roy\n                    <jats:bold>1<\/jats:bold>\n                    to HSA was evaluated by steady\u2010state fluorimetry, revealing moderate affinity near Trp\u2010214 and enhancing the thermal stability of the complex. Roy\n                    <jats:bold>1<\/jats:bold>\n                    exhibits excellent aqueous stability (0.1\u00a0mM, pH 7.4, 37\u00b0C), with similar results for two benzoylated derivatives (RoyBz and Roy12Bz), and no ester hydrolysis was detected. These findings highlight Roy\n                    <jats:bold>1<\/jats:bold>\n                    \u2019s potential as a stable, bioactive lead compound for developing PKC\u2010\u03b4\u2010targeted therapeutics, with HSA as a suitable delivery vehicle.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500670","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T21:26:27Z","timestamp":1759958787000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Plectranthus<\/i>\n                    \u2010derived Abietanes as Protein Kinase C\u2010\u03b4 Activators: In Silico Design, Human Serum Albumin Interaction, and Stability Evaluation"],"prefix":"10.1002","volume":"22","author":[{"given":"Vera M. 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