{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T13:03:18Z","timestamp":1773493398544,"version":"3.50.1"},"reference-count":66,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cyanobacteria are photosynthetic microorganisms known for producing diverse bioactive compounds. This study explores the bioactivity of extracts and fractions from Amazonian cyanobacteria and their pigment and phenolic compound production. A fraction from\n                    <jats:italic>Synechococcus<\/jats:italic>\n                    sp. CACIAM 05 showed cytotoxicity against hCMEC\/D3 and MG\u201063 cells. UPLC\u2010HRMS\/MS analysis of this fraction (C5FD) identified pheophytin and phorbide derivatives as key bioactive molecules. In antimicrobial assays, another fraction from the same strain exhibited bactericidal activity against\n                    <jats:italic>Bacillus subtilis<\/jats:italic>\n                    ATCC 6633, with a MIC of 40\u00a0\u00b5g\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    . Additional strains also showed antibacterial effects, though with higher MICs. Allelopathic activity identified eleven bioactive strains, including a synergistic effect between\n                    <jats:italic>Desmonostoc<\/jats:italic>\n                    sp. CACIAM 45 and\n                    <jats:italic>Synechocystis<\/jats:italic>\n                    sp. CACIAM 05. Aqueous extracts from\n                    <jats:italic>Lyngbya<\/jats:italic>\n                    sp. CACIAM 07 and\n                    <jats:italic>Desmonostoc<\/jats:italic>\n                    sp. CACIAM 45 showed the highest total phenolic content. Cultivation of\n                    <jats:italic>Desmonostoc<\/jats:italic>\n                    sp. CACIAM 45 in different media indicated CHU\u201010 and ASM as optimal for phenolic and phycobiliprotein production. These findings contribute to the field by unveiling novel bioactivities and metabolic profiles of Amazonian cyanobacteria, supporting their potential as a valuable source of natural products for pharmaceutical and biotechnological applications.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501582","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T18:16:12Z","timestamp":1758564972000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Amazonian Cyanobacteria as a Source of Bioactive Compounds With Antimicrobial and Cytotoxic Properties"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0822-6392","authenticated-orcid":false,"given":"Samuel","family":"Cavalcante do Amaral","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Biotecnologia de Enzimas e Biotransforma\u00e7\u00f5es , Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal do Par\u00e1 Bel\u00e9m Par\u00e1 Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0913-8765","authenticated-orcid":false,"given":"Luciana Pereira","family":"Xavier","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biotecnologia de Enzimas e Biotransforma\u00e7\u00f5es , Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal do Par\u00e1 Bel\u00e9m Par\u00e1 Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8737-2138","authenticated-orcid":false,"given":"Mariana","family":"Reis","sequence":"additional","affiliation":[{"name":"CIIMAR\/CIMAR \u2010 Interdisciplinary Centre of Marine and Environmental Research University of Porto Matosinhos Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9080-1228","authenticated-orcid":false,"given":"Rhuana V.","family":"M\u00e9dice","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Ci\u00eancias Farmac\u00eauticas 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