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The compounds that had potency lower than 20 \u00b5M were those with the experimental hydrophobicity (log\n                    <jats:italic>\n                      k\n                      <jats:sub>w<\/jats:sub>\n                    <\/jats:italic>\n                    ) in the range of 3.90 \u2013 4.47, e.g., mesoionic compound containing nitro\u2010moiety (\n                    <jats:bold>14<\/jats:bold>\n                    , IC\n                    <jats:sub>50<\/jats:sub>\n                    = 7.78 \u00b1 0.06\u00a0\u00b5M) was identified as the leading compound to inhibit Ehrlich tumor proliferation, following the best docking score values obtained to KIT kinase domain and inducible nitric oxide synthase. In contrast, the mesoionic compound with hydroxy\u2010moiety (\n                    <jats:bold>9<\/jats:bold>\n                    , IC\n                    <jats:sub>50<\/jats:sub>\n                    = 5.92 \u00b1 0.67\u00a0\u00b5M) in the styryl aromatic ring was the most active in S180 tumour cells. The synergism of the natural flavonoid Quercetin with\n                    <jats:bold>14<\/jats:bold>\n                    and\n                    <jats:bold>9<\/jats:bold>\n                    was in vivo evaluated, opening new avenues to antitumoral treatment.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501903","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:48:43Z","timestamp":1759528123000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Antitumoral Profile of 1,3,4\u2010Thiadiazolium Salts: Insights Into a Combinatory Therapeutic Approach With Flavonoid Quercetin"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6211-7659","authenticated-orcid":false,"given":"Ot\u00e1vio Augusto","family":"Chaves","sequence":"first","affiliation":[{"name":"Department of Chemistry Coimbra Chemistry Centre \u2010 Institute of Molecular Science (CQC\u2010IMS) University of Coimbra  Coimbra Portugal"},{"name":"Laboratory of Immunopharmacology, Centro de Pesquisa, Inova\u00e7\u00e3o e Vigil\u00e2ncia Em COVID\u201019 e Emerg\u00eancias Sanit\u00e1rias (CPIV) Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (FIOCRUZ)  Rio de Janeiro Brazil"}]},{"given":"Juliana","family":"Echevarria\u2010Lima","sequence":"additional","affiliation":[{"name":"Paulo De G\u00f3es Institute of Microbiology Federal University of Rio de Janeiro (UFRJ)  Rio de Janeiro Brazil"}]},{"given":"Carlos","family":"Serpa","sequence":"additional","affiliation":[{"name":"Department of Chemistry Coimbra Chemistry Centre \u2010 Institute of Molecular Science (CQC\u2010IMS) University of Coimbra  Coimbra Portugal"}]},{"given":"\u00c1urea","family":"Echevarria","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry Institute of Chemistry Federal Rural University of Rio de Janeiro (UFRRJ)  Rio de Janeiro 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