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This study evaluated a mucoadhesive polyvinyl alcohol (PVA) film containing 2.5%\n                    <jats:italic>Fridericia chica<\/jats:italic>\n                    extract as a novel strategy. The formulation was characterized for antioxidant activity, phenolic and flavonoid content, and reactive species scavenging. Nanostructure size and morphology were assessed by DLS and TEM. Biological assays included antimicrobial activity, ex vivo release (Franz cells), and cytotoxicity in HGF\u20101 and HaCaT cells. The film showed antioxidant and antimicrobial activity against\n                    <jats:italic>Candida<\/jats:italic>\n                    spp. and bacterial strains, and showed no cytotoxicity up to 62.5\u00a0\u00b5g\/mL. Particles were nanometric (245.5\u00a0nm), monodisperse, with a zeta potential of \u221211.13\u00a0mV. 3\u2010Deoxyanthocyanidins and luteolin permeated the porcine esophageal membrane, indicating that PVA did not hinder compound release. The\n                    <jats:italic>F. chica<\/jats:italic>\n                    \u00a0+\u00a0PVA film may improve mucosal adhesion and sustain delivery, representing a promising alternative for mucositis treatment.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502095","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T20:29:31Z","timestamp":1761424171000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mucoadhesive Polyvinyl Alcohol Film Containing\n                    <i>Fridericia chica<\/i>\n                    Extract for Mucositis Treatment: Pharmacological Evaluation and Active Compounds Release"],"prefix":"10.1002","volume":"23","author":[{"given":"Ilza Maria","family":"de Oliveira Sousa","sequence":"first","affiliation":[{"name":"Graduate Program in Medical Sciences, School of Medical Science (FCM) Universidade Estadual de Campinas (UNICAMP)  Campinas Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5463-3784","authenticated-orcid":false,"given":"Ailane Souza","family":"de Freitas","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences (FCF) Universidade Estadual de Campinas (UNICAMP)  Campinas Brazil"}]},{"given":"Fabr\u00edcio","family":"de Faveri Favero","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences (FCF) Universidade Estadual de Campinas (UNICAMP)  Campinas Brazil"},{"name":"Department of Physiological Science\u2014Piracicaba Dental School (FOP) Universidade Estadual de Campinas (UNICAMP)  Piracicaba Brazil"}]},{"given":"Lucia Elaine O.","family":"Braga","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences (FCF) Universidade Estadual de Campinas (UNICAMP)  Campinas Brazil"}]},{"given":"Mariana Cecchetto","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Graduate Program in Medical Sciences, School of Medical Science (FCM) Universidade Estadual de Campinas (UNICAMP)  Campinas Brazil"}]},{"given":"Diana","family":"Pinto","sequence":"additional","affiliation":[{"name":"LAQV\/REQUIMTE, Faculty of Pharmacy University of Porto  Porto Portugal"}]},{"given":"Maria Beatriz P. 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