{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T01:40:45Z","timestamp":1768009245523,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,3,22]],"date-time":"2012-03-22T00:00:00Z","timestamp":1332374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p>Subsarcolemmal (SS) and intermyofibrillar (IMF) mitochondria exhibit unique biochemical and functional properties; however, their association with structural membrane proteins that control mitochondrial morphology and functionality in striated muscle tissue was never reported. In IMF and SS mitochondria isolated from rat heart and <jats:italic>gastrocnemius<\/jats:italic> muscle, we analysed the expression levels of mitofilin, a mitochondria\u2010associated protein involved in organelle structure maintenance. The statistically significant higher amounts of mitofilin detected in IMF compared with SS mitochondria, 37\u2010fold in cardiac tissue and 3.8\u2010fold in <jats:italic>gastrocnemius<\/jats:italic>, together with the specific energetic requirements of these mitochondrial populations highlight the importance of mitofilin in oxidative phosphorylation functionality and in mitochondrial plasticity in striated muscle. The differential expression levels of mitofilin between IMF and SS also suggest that this protein can be used as a specific molecular marker to comparatively discriminate spatially distant mitochondrial populations. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cbf.2811","type":"journal-article","created":{"date-parts":[[2012,3,22]],"date-time":"2012-03-22T23:26:56Z","timestamp":1332458816000},"page":"395-399","source":"Crossref","is-referenced-by-count":8,"title":["Spatially distinct mitochondrial populations exhibit different mitofilin levels"],"prefix":"10.1002","volume":"30","author":[{"given":"Rita M. 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