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Beyond tryptamines, the secondary metabolome of these fungi is poorly understood. The genomes of five species (<jats:italic>P. azurescens<\/jats:italic>, <jats:italic>P. cubensis<\/jats:italic>, <jats:italic>P.\u2005cyanescens<\/jats:italic>, <jats:italic>P. mexicana<\/jats:italic>, and <jats:italic>P. serbica<\/jats:italic>) were browsed to understand more profoundly common and species\u2010specific metabolic capacities. The genomic analyses revealed a much greater and yet unexplored metabolic diversity than evident from parallel chemical analyses. <jats:italic>P. cyanescens<\/jats:italic> and <jats:italic>P. mexicana<\/jats:italic> were identified as aeruginascin producers. Lumichrome and verpacamide A were also detected as <jats:italic>Psilocybe<\/jats:italic> metabolites. The observations concerning the potential secondary metabolome of this fungal genus support pharmacological and toxicological efforts to find a rational basis for yet elusive phenomena, such as paralytic effects, attributed to consumption of some magic mushrooms.<\/jats:p>","DOI":"10.1002\/cbic.202200249","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T12:14:47Z","timestamp":1652876087000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Genetic Survey of <i>Psilocybe<\/i> Natural Products"],"prefix":"10.1002","volume":"23","author":[{"given":"Sebastian","family":"D\u00f6rner","sequence":"first","affiliation":[{"name":"Department Pharmaceutical Microbiology at the Hans-Kn\u00f6ll-Institute Friedrich-Schiller-Universit\u00e4t  Beutenbergstrasse 11a 07745 Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Rogge","sequence":"additional","affiliation":[{"name":"Department Pharmaceutical Microbiology at the Hans-Kn\u00f6ll-Institute Friedrich-Schiller-Universit\u00e4t  Beutenbergstrasse 11a 07745 Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6443-3185","authenticated-orcid":false,"given":"Janis","family":"Fricke","sequence":"additional","affiliation":[{"name":"Department Pharmaceutical Microbiology at the Hans-Kn\u00f6ll-Institute Friedrich-Schiller-Universit\u00e4t  Beutenbergstrasse 11a 07745 Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Department Pharmaceutical Microbiology at the Hans-Kn\u00f6ll-Institute Friedrich-Schiller-Universit\u00e4t  Beutenbergstrasse 11a 07745 Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob M.","family":"Wurlitzer","sequence":"additional","affiliation":[{"name":"Department Pharmaceutical Microbiology at the Hans-Kn\u00f6ll-Institute Friedrich-Schiller-Universit\u00e4t  Beutenbergstrasse 11a 07745 Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5669-7618","authenticated-orcid":false,"given":"Markus","family":"Gressler","sequence":"additional","affiliation":[{"name":"Department Pharmaceutical Microbiology at the Hans-Kn\u00f6ll-Institute Friedrich-Schiller-Universit\u00e4t  Beutenbergstrasse 11a 07745 Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duyen N. 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