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A <jats:italic>T. lanuginosus<\/jats:italic> lipase\u2010palladium nanoparticles hybrid (Pd@TLL) was synthesized, yielding PdNPs with an average diameter size of 5\u2005nm. This heterogeneous catalyst was first tested in the selective oxidation of benzyl alcohol to benzaldehyde in different solvents. Then, the direct formation of bis(3\u2010indolyl)methane, by <jats:italic>in\u2005situ<\/jats:italic> oxidation and C\u2212C coupling, was successfully evaluated under different conditions, obtaining &gt;99\u2009% conversion at 80\u2009\u00b0C in toluene, with a TOF value of 9\u2005min<jats:sup>\u22121<\/jats:sup> and 89\u2009% in pure water<jats:sup>,<\/jats:sup> demonstrating the versatility of these biohybrids.<\/jats:p>","DOI":"10.1002\/cctc.202300748","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T18:23:54Z","timestamp":1701109434000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Exploring <i>Thermomyces lanuginosus<\/i> Lipase (TLL)\u2010PdNPs Nanohybrid as Suitable Catalyst for One\u2010pot Synthesis of Bis(3\u2010indolyl)phenylmethane"],"prefix":"10.1002","volume":"16","author":[{"given":"A. Sofia","family":"Santos","sequence":"first","affiliation":[{"name":"Instituto de Cat\u00e1lisis y Petroleoqu\u00edmica (ICP) CSIC  28049 Madrid Spain"},{"name":"LAQV@REQUIMTE Department of Chemistry NOVA School of Science and Technology Universidade Nova de Lisboa  2829-516 Caparica Portugal"},{"name":"LAQV@REQUIMTE Department of Chemistry University of Aveiro  3810-193 Aveiro Portugal"}]},{"given":"Noelia","family":"Losada\u2010Garcia","sequence":"additional","affiliation":[{"name":"Instituto de Cat\u00e1lisis y Petroleoqu\u00edmica (ICP) CSIC  28049 Madrid Spain"}]},{"given":"Carla","family":"Garcia\u2010Sanz","sequence":"additional","affiliation":[{"name":"Instituto de Cat\u00e1lisis y Petroleoqu\u00edmica (ICP) CSIC  28049 Madrid Spain"}]},{"given":"Artur M. S.","family":"Silva","sequence":"additional","affiliation":[{"name":"LAQV@REQUIMTE Department of Chemistry University of Aveiro  3810-193 Aveiro Portugal"}]},{"given":"M. Manuel B.","family":"Marques","sequence":"additional","affiliation":[{"name":"LAQV@REQUIMTE Department of Chemistry NOVA School of Science and Technology Universidade Nova de Lisboa  2829-516 Caparica Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6464-1216","authenticated-orcid":false,"given":"Jose M.","family":"Palomo","sequence":"additional","affiliation":[{"name":"Instituto de Cat\u00e1lisis y Petroleoqu\u00edmica (ICP) CSIC  28049 Madrid Spain"}]}],"member":"311","published-online":{"date-parts":[[2023,12,14]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112506"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570179417666200124103400"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1380415"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.catcom.2020.106240"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2021.152936"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.202100621"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.1c02702"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/catal3020486"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2RA21887A"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2NJ02525F"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2020.102316"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112951"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano10020292"},{"key":"e_1_2_8_14_1","first-page":"357","volume-title":"Green Chemistry for Environmental Remediation","author":"Rani A.","year":"2012"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/15533174.2015.1016315"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA04893E"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.4431"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matpr.2021.02.327"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202000270"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9RA10014H"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.202300701"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/applnano2010001"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2NA00742H"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.201801294"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jssc.2010.07.013"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.7b01603"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201300744"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201200881"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9RA10014H"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/open.202200265"}],"container-title":["ChemCatChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cctc.202300748","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:37:13Z","timestamp":1760301433000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cctc.202300748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,14]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,2,8]]}},"alternative-id":["10.1002\/cctc.202300748"],"URL":"https:\/\/doi.org\/10.1002\/cctc.202300748","archive":["Portico"],"relation":{},"ISSN":["1867-3880","1867-3899"],"issn-type":[{"value":"1867-3880","type":"print"},{"value":"1867-3899","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,14]]},"assertion":[{"value":"2023-06-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202300748"}}