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With the technological advancements of these processes (especially for light olefins), which have importantly contributed to the epoxides market expansion, challenges remain in developing adequate heterogeneous catalysts for converting bulkier olefins, using simple catalyst synthesis procedures, and, on the other hand, studying the catalytic performances under different operation modes. Hence, heterogeneous epoxidation catalysts are prepared via simple one\u2010pot procedures, with the necessary versatility to tune the material properties for batch and continuous flow operation. Specifically, silica\u2010embedded nanoparticles of molybdenum oxide (Si\/Mo(x), x = Mo loading) and silica\u2010embedded nanoparticles of binary transition metal oxides (Si\/MoM, M = Ta, Nb or W) are synthesized, and promoted the epoxidation of <jats:italic>cis<\/jats:italic>\u2010cyclooctene with <jats:italic>tert<\/jats:italic>\u2010butylhydroperoxide as oxidant, at 70\u00a0\u00b0C. Epoxide yields in the range of 90%\u2013100% are reached within 4 h, at 70\u00a0\u00b0C, under batch operation. Under continuous flow, steady state conditions (fixed bed reactor), catalyst Si\/MoNb led to ca. 44% epoxide yield, at 70\u00a0\u00b0C. At 90\u00a0\u00b0C, Si\/MoNb exhibited multifunctionality leading to 51% cyclooctanone yield. It represents the first fully inorganic heterogeneous Mo\u2010catalyst for continuous flow olefin epoxidation and the first heterogeneous Mo\u2010catalyst for integrated olefins\u2010to\u2010cycloalkanones with hydroperoxides.<\/jats:p>","DOI":"10.1002\/cctc.202500003","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T10:55:57Z","timestamp":1741690557000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Silica\u2010Embedded Metal Oxide Nanoparticles as Epoxidation Catalysts: Batch and Continuous Flow Systems"],"prefix":"10.1002","volume":"17","author":[{"given":"Diana M.","family":"Gomes","sequence":"first","affiliation":[{"name":"Department of Chemistry CICECO\u2010Aveiro Institute of Materials University of Aveiro Campus Universit\u00e1rio de Santiago  Aveiro 3810\u2010193 Portugal"}]},{"given":"Xingyu","family":"Yao","sequence":"additional","affiliation":[{"name":"Department 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